How thalidomide works The first effect of thalidomide, which was discovered in the 1950s, is based on the imitation of a messenger substance in the brain (neurotransmitter). This neurotransmitter – known as GABA – is the most important inhibitory messenger substance in the brain. It reduces communication between nerve cells, which makes people sleepy. Thalidomide … Thalidomide: effects, areas of application, side effects
Products TNF-α inhibitors are commercially available as injectable and infusion preparations. Infliximab (Remicade) was the first agent from this group to be approved in 1998, and in many countries in 1999. Biosimilars of some representatives are now available. Others will follow in the next few years. This article refers to biologics. Small molecules can also … TNF-Α Inhibitors
Definition Amides are organic compounds containing a carbonyl group (C=O) whose carbon atom is bonded to a nitrogen atom. They have the following general structure: R1, R2 and R3 can be aliphatic and aromatic radicals or hydrogen atoms. Amides can be synthesized with a carboxylic acid (or a carboxylic acid halide) and an amine using … Amide
Products Lenalidomide is commercially available in the form of hard capsules (Revlimid). It has been approved in many countries since 2007. Generic versions were registered in 2019. Structure and properties Lenalidomide (C13H13N3O3, Mr = 259.3 g/mol) is a derivative of thalidomide and exists as a racemate. Effects Lenalidomide (ATC L04AX04) has immunomodulatory and antiangiogenic properties. … Lenalidomide
Products Pamidronate is commercially available as an injectable (Aredia, generic). Aredia had been approved in many countries since 1993. Sales of Aredia were discontinued in 2016. Structure and properties Pamidronate is present in drugs as pamidronate disodium (C3H9NNa2O7P2, Mr = 279.0 g/mol) is present, a nitrogen-containing bisphosphonate that is soluble in water. Effects Pamidronate (ATC … Pamidronate
Products Pomalidomide is commercially available in the form of hard capsules (Imnovid). It has been approved in many countries since 2014. It has been registered in the EU and the United States since 2013. Structure and properties Pomalidomide (C13H11N3O4, Mr = 273.2 g/mol) is an amino derivative of thalidomide and a racemate. It is also … Pomalidomide
Thalidomide is a drug from the class of sedatives. It led to the thalidomide scandal due to damage to unborn children. What is thalidomide? Thalidomide is a drug from the class of sedatives. It led to the thalidomide scandal by causing damage to unborn children. The active ingredient thalidomide, also known as α-phthalimidoglutarimide, was formerly … Thalidomide: Effects, Uses & Risks
