Pyridoxine

Products

Pyridoxine (vitamin B6) is contained in numerous medicines and dietary supplements and is commercially available, for example, in the form of tablets, effervescent tablets, lozenges and as juice. Many products are combination preparations with other vitamins, minerals and trace elements. Monopreparations include Burgerstein vitamin B6, Benadon and vitamin B6 Streuli.

Structure and properties

Pyridoxine or vitamin B6 is usually present in drugs as pyridoxine hydrochloride (C₈H₁₂ClNO₃, M_r = 205.6 g/mol), a white crystalline powder that is readily soluble in water. Pyridoxine is a prodrug that is biotransformed in the organism to the active pyridoxal phosphate (PLP, pyridoxal 5′-phosphate).

Effects

Pyridoxine (ATC A11HA02), in its active form PLP, is a cofactor of numerous enzymes that play important roles in amino acid, lipid, and carbohydrate metabolism, among others.

Indications and indications

• For the prevention and treatment of pyridoxine deficiency.
• Nausea and vomiting, motion sickness see under pyridoxine for nausea.

Dosage

According to the professional information.

Contraindications

• Hypersensitivity

For complete precautions, see the drug label.

Interactions

Drug interactions are possible with the following agents, among others:

• Isoniazid
• Hydralazine
• Penicillamine
• Cycloserine
• Levodopa
• Phenytoin
• Phenobarbital

Adverse effects

Possible adverse effects include skin reactions.