Pathogenesis (disease development)
Acoustic neuroma (AKN) is a benign (benign) tumor arising from the Schwanńs cells of the vestibular portion of the VIIIth cranial nerve. Cranial nerve, the auditory and vestibular nerves (vestibulocochlear nerve, acustic nerve; octaval nerve), and is located in the internal auditory canal, or at greater extension in the cerebellopontine angle.
Etiology (Causes)
The exact etiology is unknown.
Biographic causes
- Genetic disorders
- Neurofibromatosis – genetic disease with autosomal dominant inheritance; belongs to the phakomatoses (diseases of the skin and nervous system); three genetically distinct forms are distinguished:
- Neurofibromatosis type 1 (von Recklinghausen’s disease) – patients develop multiple neurofibromas (nerve tumors) during puberty, which often occur in the skin but also occur in the nervous system, orbita (eye socket), gastrointestinal tract (gastrointestinal tract), and retroperitoneum (space located behind the peritoneum on the back toward the spine); The appearance of café-au-lait spots (CALF; light brown macules/spots) and multiple benign (benign) neoplasms is typical
- Neurofibromatosis type 2 – characterized by bilateral (bilateral) acoustic neuroma (vestibular schwannoma) and multiple meningiomas (meningeal tumors).
- Schwannomatosis – hereditary tumor syndrome.
- Neurofibromatosis – genetic disease with autosomal dominant inheritance; belongs to the phakomatoses (diseases of the skin and nervous system); three genetically distinct forms are distinguished:
