Digitoxin: Drug Effects, Side Effects, Dosage and Uses

Structure and properties

Digitoxin (C₄₁H₆₄O₁₃, M_r = 765 g/mol) exists as a white powder that is practically insoluble in water. It occurs naturally in -species as a natural plant constituent.

Effects

Digitoxin (ATC C01AA04) has positive inotropic, negative chronotropic, negative dromotropic, and positive bathmotropic properties. It has a long half-life of up to 8 days and, consequently, a long duration of action.

Indications

• Chronic heart failure
• Cardiac arrhythmias
• Fatigue symptoms of muscular, accommodative or nervous nature in the eye (eye drops).