Products
Synthetic FimH antagonists are currently in clinical development and not yet commercially available. The natural simple sugar D-mannose is also effective as a FimH antagonist and is available in some countries. However, it binds more weakly to the drug target and must be dosed at high levels.
Effects
FimH antagonists bind to the protein FimH at the tip of type 1 pili uropathogenic bacteria such as (UPEC). These pili are responsible for bacterial adhesion to the bladder urothelium, which is the first step in infection. The agents prevent the bacteria from attaching to the bladder and penetrating the urothelial cells. They allow the bacteria to be flushed out with urine.
Indications
For prevention and treatment of bladder infections and other urinary tract infections.
Active ingredients
Synthetic FimH antagonists are in clinical development. D-mannose is a natural FimH antagonist (see under D-mannose).