Products
Fluocinonide is commercially available as a cream and ointment in mono and combination formulations (Topsym). It has been approved in many countries since 1971.
Structure and properties
Fluocinonide (C26H32F2O7, Mr = 494.5 g/mol) is a fluorinated glucocorticoid.
Effects
Fluocinonide (ATC D07AC08) has anti-inflammatory, antiallergic, antipruritic, and immunosuppressive properties. The effects are due to binding to intracellular glucocorticoid receptors.
Indications
For the treatment of inflammatory and noninfectious skin diseases.
Dosage
According to the professional information. The drugs are applied thinly twice daily (in the morning and evening). They should be administered only for short periods and over small areas because of the possible adverse effects.
Contraindications
- Hypersensitivity
- Infected skin diseases
- Vaccination reactions
- Perioral dermatitis
- Rosacea
- Skin ulcers
- Acne
- The drug should not get into the eyes.
The full precautions can be found in the drug label.
Interactions
Interactions with other drugs are not known to date.
Adverse effects
Possible adverse effects include local reactions such as irritation, burning, itching, dryness, and hypersensitivity reactions. As with all topical glucocorticoids, adverse skin reactions may occur if used improperly.
