Products Prednicarbate is commercially available as a cream, solution, and ointment (Prednitop, Prednicutan). It has been approved in many countries since 1990. Structure and properties Prednicarbate (C27H36O8, Mr = 488.6 g/mol) belongs to the class of potent glucocorticoids (class III). It is a non-halogenated prednisolone derivative. It exists as an odorless, white to yellowish-white, crystalline … Prednicarbate
Products and production Hydrocortisone soft ointments are manufactured in 1% or 2% concentrations in pharmacies as extemporaneous preparations. Concentration: 1% 2% Hydrocortisone acetate 1.0 2.0 Soft ointment KA or Unguentum Cordes 99.0 98.0 Recipe DMS The soft ointment consists mostly of viscous kerosene and petrolatum. The manufacturing prescription can be found in the DMS. Effects … Hydrocortisone Soft Ointment
Products To date, hydrocortisone acetate is the only glucocorticoid approved for self-medication in many countries and is available without a doctor’s prescription. A cream (Dermacalm with dexpanthenol) and a hydrocream (Sanadermil) are available. Hydrocortisone was the first dermocorticoid and was introduced in the 1950s. Structure and properties Hydrocortisone acetate (C23H32O6, Mr = 404.5 g/mol) is … Hydrocortisone Acetate
Products Hydrocortisone butyrate is commercially available as emulsion and cream (Locoid). It has been approved in many countries since 1973. Structure and properties Hydrocortisone-17-butyrate (C25H36O6, Mr = 432.6 g/mol) is an esterified, nonhalogenated glucocorticoid. It is a derivative of endogenous hydrocortisone. Effects Hydrocortisone butyrate (ATC D07AB02) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. The effects … Hydrocortisone Butyrate
Products Methylprednisolone aceponate has been approved in many countries since 1991 and is commercially available as cream, ointment, and fatty ointment (Advantan). Structure and properties Methylprednisolone aceponate (C27H36O7, Mr = 472.6 g/mol) is a lipophilic and nonhalogenated glucocorticoid that is hydrolyzed in the skin by esterases to the active metabolite 6α-methylprednisolone-17-propionate. Effects Methylprednisolone aceponate (ATC … Methylprednisolone Aceponate
Products Halcinonide was commercially available as a solution, cream, and fat cream, and was also combined fixedly with urea and salicylic acid (Betacorton, Betacorton S). It was approved in many countries in 1981. It was discontinued from 2018 to 2019. Structure and properties Halcinonide (C24H32ClFO5, Mr = 454.96 g/mol) exists as a white powder that … Halcinonide
Products Halometasone is commercially available as a cream in combination with triclosan (Sicorten plus). It has been approved in many countries since 1983. Structure and properties Halometasone (C22H27ClF2O5, Mr = 444.9 g/mol) is a chlorinated and fluorinated (halogenated) steroid. Effects Halometasone (ATC D07AC12) has anti-inflammatory, antiallergic, and immunosuppressive properties. It is a potent class III … Halometasone
Products Diflucortolone valerate has been commercially available in many countries since 1980 as a cream in fixed combination with the azole antifungal isoconazole (Travocort). Structure and properties Diflucortolone valerate (C27H36F2O5, Mr = 478.6 g/mol) Effects Diflucortolone valerate (ATC D07AC06) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. Indications In many countries, diflucortolone valerate is marketed exclusively … Diflucortolone Valerate
Products Fluprednidene acetate is commercially available as a cream in many countries and has been approved since 1993 (Decoderm bivalent + miconazole nitrate). Structure and properties Fluprednidene acetate (C24H29FO6, Mr = 432.5 g/mol) Effects Fluprednidene acetate (ATC D07AB07) has anti-inflammatory, antiallergic, antipruritic, and antiproliferative properties. The effects are due to binding to intracellular glucocorticoid receptors. … Fluprednidene Acetate
Products Fluocinonide is commercially available as a cream and ointment in mono and combination formulations (Topsym). It has been approved in many countries since 1971. Structure and properties Fluocinonide (C26H32F2O7, Mr = 494.5 g/mol) is a fluorinated glucocorticoid. Effects Fluocinonide (ATC D07AC08) has anti-inflammatory, antiallergic, antipruritic, and immunosuppressive properties. The effects are due to binding … Fluocinonide
Products Fluocinolone acetonide is commercially available as an ointment, cream, and suppositories (Synalar, Procto-Synalar N). It has been approved in many countries since 1963. Structure and properties Fluocinolone acetonide (C24H30F2O6, Mr = 452.5 g/mol) exists as a white crystalline powder that is practically insoluble in water. It is a fluorinated and fused glucocorticoid. Effects Fluocinolone … Fluocinolone Acetonide
Products Desonide was commercially available as a cream (Locapred). It had been approved in many countries since 1983. It was discontinued in 2020. Structure and properties Desonide (C24H32O6, Mr = 416.5 g/mol) is a nonfluorinated, fused glucocorticoid. It exists as a white and odorless powder that is practically insoluble in water. Effects Desonide (ATC D07AB08) … Desonid
