Monoclonal Gammopathy

Monoclonal Gammopathy: Test and Diagnosis

1st order laboratory parameters – obligatory laboratory tests. Small blood count [plasmocytoma/multiple myeloma: normochromic anemia (anemia), leukopenia (decreased white blood cell count), and thrombocytopenia (decreased platelet count); final may be pancytopenia (synonym: tricytopenia: decrease in all three cell series in the blood; stem cell disease)] Differential blood count Inflammatory parameters – CRP (C-reactive protein) or … Monoclonal Gammopathy: Test and Diagnosis

Monoclonal Gammopathy: Diagnostic Tests

Obligatory medical device diagnostics. X-ray of the thorax (radiographic thorax), in two planes and skeleton, or long bones, spine, and skull – to exclude osteolysis [plasmacytoma/multiple myeloma: skull radiograph shows typical “shotgun skull”; occasionally unremarkable in early stages; monoclonal gammopathy: no skeletal destruction] Optional medical device diagnostics – depending on the results of the history, … Monoclonal Gammopathy: Diagnostic Tests

Monoclonal Gammopathy: Symptoms, Complaints, Signs

Depending on the severity and extent of the disease, different symptoms may be seen. The following symptoms and complaints may indicate monoclonal gammopathy: Bone pain Increased susceptibility to infections Fatigue Crystalline keratopathy (disease of the cornea of the eye), “salt mannoids”, latticed or patchy deposits – as corneal manifestation.

Monoclonal Gammopathy: Medical History

Medical history (history of illness) represents an important component in the diagnosis of monoclonal gammopathy. Family History Is there a history of frequent tumors in your family? Social history What is your profession? Are you exposed to harmful working substances in your profession? Current medical history/systemic medical history (somatic and psychological complaints). What complaints have … Monoclonal Gammopathy: Medical History

Monoclonal Gammopathy: Or something else? Differential Diagnosis

Endocrine, nutritional, and metabolic diseases (E00-E90). Amyloidosis – extracellular (“outside the cell”) deposition of amyloids (degradation-resistant proteins); possible symptoms: purpura (capillary hemorrhage), cardiomyopathy (heart muscle disease), macroglossia (enlargement of the tongue, carpal tunnel syndrome (KTS), peripheral neuropathy (disease of the peripheral nervous system), nephrotic syndrome Musculoskeletal system and connective tissue (M00-M99). Osteoporosis (bone loss) Rheumatism … Monoclonal Gammopathy: Or something else? Differential Diagnosis

Monoclonal Gammopathy: Examination

A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse, body weight, height; further: Inspection (viewing). Skin, mucous membranes, and sclerae (white part of eye) [signs of pruritus (itching), anemia (anemia)?; skin hemorrhages?] Inspection and palpation (palpation) of the lymph node stations (cervical, axillary, supraclavicular, … Monoclonal Gammopathy: Examination