Therapeutic targets Relief of pain – non-osseous fibroma usually causes pain very rarely. Stabilization of bone sections at risk of fracture Healing Therapy recommendations Analgesia according to WHO staging scheme: Non-opioid analgesic (paracetamol, first-line agent). Low-potency opioid analgesic (e.g., tramadol) + non-opioid analgesic. High-potency opioid analgesic (eg, morphine) + non-opioid analgesic.
Obligatory medical device diagnostics. Conventional radiograph of affected body region, in two planes – to assess extent of tumor growth; NOF appears cystic, marginal; often clustered grape-shaped brightenings with dense, garland-shaped marginal sclerosis; lesion may cross bone borders If necessary, computed tomography (CT; sectional imaging procedure (X-ray images from different directions with computer-based evaluation)) – … Nonossifying Fibroma: Diagnostic Tests
Medical history (history) is an important component in the diagnosis of nonossifying fibroma (NOF). Family history Are there any diseases in your family that are common? (Tumor diseases) Social anamnesis Current medical history/systemic history (somatic and psychological complaints). Do you suffer from persistent or increasing pain in the skeletal system for which there is no … Nonossifying Fibroma: Medical History
Musculoskeletal system and connective tissue (M00-M99). Aneurysmal bone cyst – aggressive, expansive growing cyst. Fibrous dysplasia – malformation of bone tissue, that is, the bones form tumor-like protrusions. Neoplasms – tumor diseases (C00-D48). Benign (benign) fibrous histiocytoma (BFH; synonym: dermatofibroma). Chondroma, periosteal (affecting the periosteum) – benign tumor that forms mature cartilage tissue. Symptoms and … Nonossifying Fibroma: Or something else? Differential Diagnosis
The following are the most important diseases or complications that may be contributed to by nonossifying fibroma (NOF): Injury, poisoning, and other sequelae of external causes (S00-T98). Pathologic fractures (broken bones) – due to the bone tumor, the affected bone loses strength
A comprehensive clinical examination is the basis for selecting further diagnostic steps: General physical examination – including blood pressure, pulse,body weight, height; furthermore: Inspection (viewing). Skin and mucous membranes Extremities Gait pattern (fluid, limping) Auscultation (listening) of the heart. Auscultation of the lungs Palpation (palpation) of the painful area [pressure pain, pain on movement, pain … Nonossifying Fibroma: Examination
Larger lesions may increase the risk of fracture (bone breakage). The bone defect can be filled with cancellous bone (bone bellicles; these give the bone stability, or resistance to fracture). Stabilization of the area at risk is another option.
A nonossifying fibroma is almost always asymptomatic and therefore usually an incidental finding on radiography. The following symptoms and complaints may indicate a nonossifying fibroma (NOF): Uncharacteristic pulling pain (rare) – usually on the inside of the knee joint. Localization Typical for primary bone tumors is that they can be assigned to a characteristic localization … Nonossifying Fibroma: Symptoms, Complaints, Signs
Pathogenesis (disease development) Nonossifying fibroma originates in connective tissue and is composed of fibroblasts (connective tissue cells), histiocytes (tissue macrophages/eating cells), and osteoclasts (bone-degrading cells). It is pea to chestnut in size and results from a disturbance in the development and mineralization of growing bone (developmental anomaly). Small defects in the cortical bone (outer layer … Nonossifying Fibroma: Causes
General measures Nicotine restriction (refraining from tobacco use). Limited alcohol consumption (men: max. 25 g alcohol per day; women: max. 12 g alcohol per day). Limited caffeine consumption (max 240 mg of caffeine per day; equivalent to 2 to 3 cups of coffee or 4 to 6 cups of green/black tea). Aim for normal weight! … Nonossifying Fibroma: Therapy
