Pathogenesis (disease development)
Nonossifying fibroma originates in connective tissue and is composed of fibroblasts (connective tissue cells), histiocytes (tissue macrophages/eating cells), and osteoclasts (bone-degrading cells). It is pea to chestnut in size and results from a disturbance in the development and mineralization of growing bone (developmental anomaly).
Small defects in the cortical bone (outer layer of bone) are called fibrous cortical defects, and larger lesions extending inward are called nonossifying fibromas.
Etiology (Causes)
The exact causes of bone tumors are still unclear.
