Products Entecavir is commercially available as film-coated tablets and as an oral solution (Baraclude). It has been approved in many countries since 2006. Generic versions have been available since 2017. Structure and properties Entecavir (C12H15N5O3, Mr = 277.3 g/mol) is a 2′-deoxyguanosine nucleoside analog. It exists as a white powder that is sparingly soluble in … Entecavir
Products Valaciclovir is commercially available in the form of film-coated tablets (Valtrex, generic). It has been approved in many countries since 1995. Structure and properties Valaciclovir (C13H20N6O4, Mr = 324.3 g/mol) is the ester of the natural amino acid valine and the antiviral drug aciclovir. It is present in drugs as valaciclovir hydrochloride, a white … Valaciclovir
Products Valganciclovir is commercially available in the form of film-coated tablets (Valcyte). It has been approved in many countries since 2001. Generic versions were registered in 2014. Structure and properties Valganciclovir (C14H22N6O5, Mr = 354.4 g/mol) is an L-valine ester prodrug of ganciclovir and is present in the drug product as valganciclovir hydrochloride, a white … Valganciclovir
Products Penciclovir is commercially available as a cream and tinted cream (Fenivir). It has been approved in many countries since 1997. Famvir cream is out of commerce. Structure and properties Penciclovir (C10H15N5O3, Mr = 253.3 g/mol) is a mimetic of the DNA building block 2′-deoxyguanosine and is structurally related to aciclovir. It exists as a … Penciclovir
Products Brivudine is commercially available in tablet form (Brivex). It has been approved in many countries since 2003. It was originally developed in the German Democratic Republic. Structure and properties Brivudine (C11H13BrN2O5, Mr = 333.1 g/mol) is a nucleoside analog related to thymidine. Effects Brivudine (ATC J05AB) has antiviral properties against herpes viruses. It inhibits … Brivudine
Products Telbivudine is commercially available in the form of film-coated tablets (Sebivo). It has been approved in many countries since 2006. The solution has been off the market since 2012. Structure and properties Telbivudine (C10H14N2O5, Mr = 242.2 g/mol) is a thymidine analog and a prodrug that is biotransformed in cells to the active metabolite … Telbivudine
Products Cidofovir was initially marketed in many countries as an infusion concentrate under the brand name Vistide (Gilead). It was approved in many countries in 1997 and had not been available since 2014. In 2017, a concentrate for the preparation of an infusion solution was approved (Sidovis). Structure and properties Cidofovir (C8H14N3O6P, Mr = 279.2 … Cidofovir
Products Remdesivir is commercially available as a powder for a concentrate for the preparation of an infusion solution (Veklury, Gilead Sciences Inc, USA). Provisional approval was granted in many countries and in the EU in July 2020. On November 25, 2020, the approval will be granted. In the U.S., the drug was registered in October. … Remdesivir
Products Famciclovir is commercially available in the form of film-coated tablets (Famvir). It has been approved in many countries since 1995. Structure and properties Famciclovir (C14H19N5O4, Mr = 321.3 g/mol) is the orally available prodrug of penciclovir, which is itself a prodrug of penciclovir triphosphate. Famciclovir exists as a white to yellowish powder that is … Famciclovir
Products Idoxuridine has been approved as a solution in many countries since 1980 (Virexen, for export). Virunguent ointment is out of commerce and no longer available. Structure and properties Idoxuridine (C9H11IN2O5, Mr = 354.1 g/mol) is a white crystalline powder that is sparingly soluble in water. Effects Idoxuridine (ATC D06BB01) is antiviral against herpes viruses. … Idoxuridine
Products Ganciclovir is commercially available as a lyophilizate for the preparation of an infusion solution (Cymevene). It has been approved in many countries since 1988. Furthermore, an ophthalmic gel was registered in 2020. Structure and properties Ganciclovir (C9H13N5O4, Mr = 255.2 g/mol) is present in drugs as ganciclovir sodium, a white crystalline powder that is … Ganciclovir
Products Aciclovir is commercially available as film-coated tablets, cream, aciclovir lip cream, injectable, and suspension (Zovirax, generic). This article refers to the film-coated tablets. Aciclovir eye ointment is currently no longer marketed in many countries. Aciclovir was developed in the 1970s by the British company Burroughs Wellcome (Elion et al. 1977). It has been approved … Aciclovir Effects and Side Effects
