Products Bextra film-coated tablets are no longer on the market in many countries. Approval was withdrawn in April 2005 because rare severe skin reactions had occurred during treatment (see below). Structure and properties Valdecoxib (C16H14N2O3S, Mr = 314.4 g/mol) is a phenylisoxazole and a benzenesulfonamide derivative. It has a V-shaped structure with which it binds … Valdecoxib
Products Parecoxib is commercially available in Germany as a powder for solution for injection (Dynastat). It is not approved in many countries. Structure and properties Parecoxib (C19H18N2O4S, Mr = 370.4 g/mol) is a prodrug of valdecoxib that is rapidly metabolized to the active drug in vivo. Effects Parecoxib (ATC M01AH04) is analgesic and anti-inflammatory. Its … Parecoxib
Products Celecoxib is commercially available in capsule form (Celebrex, generic). It was approved in many countries in 1999 as the first member of the selective COX-2 inhibitors. Generic versions went on sale in 2014. Structure and properties Celecoxib (C17H14F3N3O2S, Mr = 381.37 g/mol) is a benzenesulfonamide and a substituted diaryl pyrazole. It has a V-shaped … Celecoxib
Products Rofecoxib was approved in many countries in 1999 in tablet and suspension form (Vioxx). It was withdrawn from the market again in late September 2004 because of adverse effects and is no longer available. Structure and properties Rofecoxib (C17H14O4S, Mr = 314.4 g/mol) is a methyl sulfone and a furanone derivative. It has a … Rofecoxib
Products Lumiracoxib (Prexige, Joicela, film-coated tablets) is no longer on the market or has not been approved in many countries because of its liver-toxic properties. The drug was not registered in many countries. Structure and properties Lumiracoxib (C15H13ClFNO2, Mr = 293.7 g/mol) is an analog of diclofenac (Voltaren) and belongs to the phenylacetic acid derivatives. … Lumiracoxib