Cymbalta helps with Depression

This active ingredient is in Cymbalta The active ingredient in Cymbalta is duloxetine. The active ingredient is a serotonin/norepinephrine reuptake inhibitor (SNRI). It binds to the transport proteins of serotonin and norepinephrine, inhibiting their transport. This increases the levels and availability of the neurotransmitters, which has a depressant and mood-lifting effect. When is Cymbalta used? … Cymbalta helps with Depression