Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Indinavir is commercially available in capsule form (Crixivan). It has been approved in many countries since 1996. Structure and properties Indinavir (C36H47N5O4, Mr = 613.8 g/mol) is present in drugs as indinavir sulfate, a white crystalline powder that is very soluble in water. Effects Indinavir (ATC J05AE02) has antiviral properties. The effects are due … Indinavir
Products Darunavir is commercially available as film-coated tablets and as an oral suspension (Prezista). It has been approved in many countries since 2006. In 2016, a fixed-dose combination with cobicistat was approved (Rezolsta film-coated tablets). In 2018, generic versions of the tablets entered the market. Structure and properties Darunavir (C27H37N3O7S, Mr = 547.7 g/mol) is … Darunavir
Products Nelfinavir was commercially available in the form of film-coated tablets (Viracept). It was approved in many countries in 1997 and withdrawn from the market in 2013 for commercial reasons. Structure and properties Nelfinavir (C32H45N3O4S, Mr = 567.8 g/mol) is present in the drug as nelfinavir mesilate, a white, amorphous powder that is sparingly soluble … Nelfinavir
Products Tipranavir is commercially available in capsule form (Aptivus). It has been approved in many countries since 2005. Structure and properties Tipranavir (C31H33F3N2O5S, Mr = 602.7 g/mol) exists as a white to slightly yellowish substance that is insoluble in an aqueous buffer at pH 7.5. Tipranavir has a nonpeptidic structure. Effects Tipranavir (ATC J05AE09) has … Tipranavir
Products Lopinavir is commercially available as film-coated tablets and as a syrup as a fixed combination with ritonavir (Kaletra). It has been approved in many countries since 2000. Structure and properties Lopinavir (C37H48N4O5, Mr = 628.8 g/mol) exists as a white to yellowish white powder that is practically insoluble in water. Effects Lopinavir (ATC J05AE06) … Lopinavir
Products Atazanavir is commercially available in capsule form (Reyataz). It has been approved in many countries since 2004. Generic versions were registered in 2017. Structure and properties Atazanavir (C38H52N6O7, Mr = 704.9 g/mol) is present in drugs as atazanavir sulfate, a white to slightly yellow crystalline powder that is sparingly soluble in water. Effects Atazanavir … Atazanavir
Products Fosamprenavir is commercially available in the form of film-coated tablets (Telzir). It has been approved in many countries since 2005. Structure and properties Fosamprenavir (C25H36N3O9PS, Mr = 585.6 g/mol) is present in drugs as fosamprenavir calcium. It is a prodrug that is rapidly biotransformed in the intestinal mucosa to the active metabolite amprenavir. Amprenavir … Fosamprenavir
Products Saquinavir is commercially available in the form of film-coated tablets (Invirase). It has been approved in many countries since 1996 (United States: 1995). Structure and properties Saquinavir (C38H50N6O5, Mr = 670.8 g/mol) is present in the drug as saquinavir mesilate, a white, weakly hygroscopic powder that is practically insoluble in water. Effects Saquinavir (ATC … Saquinavir
