Products
Indinavir is commercially available in capsule form (Crixivan). It has been approved in many countries since 1996.
Structure and properties
Indinavir (C36H47N5O4, Mr = 613.8 g/mol) is present in drugs as indinavir sulfate, a white crystalline powder that is very soluble in water.
Effects
Indinavir (ATC J05AE02) has antiviral properties. The effects are due to inhibition of HIV protease, which plays a central role in viral maturation and replication.
Indications
For the treatment of HIV infection (combination antiretroviral therapy).
Dosage
According to the SmPC. Capsules are taken every 8 hours and usually fasting, i.e., one hour before or two hours after a meal. It is also possible to take with a light meal.
Contraindications
Indinavir contraindicated in case of hypersensitivity and must not be combined with certain drugs. For complete precautions, see the drug label.
Interactions
Indinavir is metabolized by CYP3A4. Appropriate drug-drug interactions are possible with CYP substrates, inhibitors, and inducers.
Adverse effects
The most common possible adverse effects include nausea, diarrhea, abdominal pain, crystalluria, kidney stones, rash, dry skin, headache, altered taste perception, weakness, and fatigue.
