Products Dasatinib is commercially available in the form of film-coated tablets (Sprycel). It has been approved in many countries since 2007. Generic versions were registered in 2020. Structure and properties Dasatinib (C22H26ClN7O2S, Mr = 488.0 g/mol) exists as a white powder that is insoluble in water. It is an aminopyrimidine derivative. Effects Dasatinib (ATC L01XE06) … Dasatinib
Products Nilotinib is commercially available in capsule form (Tasigna). It has been approved in many countries since 2007. Structure and properties Nilotinib (C28H22F3N7O, Mr = 529.5 g/mol) is present in the drug product as nilotinib hydrochloride monohydrate, a white to slightly yellowish or greenish-yellow powder. The aminopyrimidine is structurally closely related to its precursor imatinib … Nilotinib
Products Bosutinib is commercially available in the form of film-coated tablets (Bosulif). The drug was approved in many countries in 2014. Structure and properties Bosutinib (C26H29Cl2N5O3, Mr = 530.4 g/mol) is a quinoline and piperazine derivative. It is present in drugs as bosutinib monohydrate, a white to yellowish powder that is sparingly soluble in water. … Bosutinib
Products Ponatinib is commercially available in film-coated tablet form (Iclusig). It was approved in the EU in 2013 and in many countries in 2014. Structure and properties Ponatinib (C29H27F3N6O, Mr = 532.6 g/mol) is present in the drug as ponatinib hydrochloride, a white to yellow powder whose water solubility decreases with increasing pH. It is … Ponatinib
Products Imatinib is commercially available in the form of film-coated tablets (Gleevec, Gleevec GIST, generic). It has been approved in many countries since 2001. Generics came on the market in 2016. They were not approved for the treatment of gastrointestinal stromal tumors (GIST) because this indication was still protected by a patent. In 2017, imatinib … Imatinib
