Products Chlorpromazine was commercially available in various oral and parenteral dosage forms (e.g., Chlorazine, Thorazine, Largactil, Megaphene). It was first used in the 1950s as one of the first synthetic antipsychotics. Today, it is no longer a registered drug in many countries. In some countries, chlorpromazine is still on the market. Structure and properties Chlorpromazine … Chlorpromazine
Products Chlorprothixene is commercially available in the form of film-coated tablets (Truxal). It has been approved in many countries since 1960. Distribution of the so-called Truxal 5 mg tablets was discontinued in many countries in 2011 for economic reasons. Structure and properties Chlorprothixene (C18H18ClNS, Mr = 315.9 g/mol) belongs to the thioxanthenes. It is present … Chlorprothixene
Products Pimozide is no longer commercially available as a finished drug in many countries. It is still available in some countries (Orap tablets). Structure and properties Pimozide (C28H29F2N3O, Mr = 461.5 g/mol) belongs to the diphenylbutylpiperidines. It exists as a white powder that is practically insoluble in water. Effects Pimozide (ATC N05AG02) is antipsychotic. The … Pimozide
Products Pipamperone is commercially available in tablet form (dipiperone). It has been approved in many countries since 1964. Structure and properties Pipamperone (C21H30FN3O2, Mr = 375.5 g/mol) is present in drugs as pipamperondihydrochloride. It is structurally closely related to haloperidol, which also belongs to the butyrphenones. Butyrphenones, like numerous other active ingredients, originated in the … Pipamperon
Products Sertindole is commercially available in the form of film-coated tablets (Serdolect). It has been approved in many countries since 1997. Structure and properties Sertindole (C24H26ClFN4O, Mr = 440.9 g/mol) was developed as the first neuroleptic with a phenylindole structure. Effects Sertindole (ATC N05AE03) has antipsychotic properties. The effects are due to antagonism at dopamine … Sertindol
Products Levomepromazine is commercially available as film-coated tablets and oral solution (Nozinan). It has been approved in many countries since 1958. Structure and properties Levomepromazine (C19H24N2OS, Mr = 328.5 g/mol) is present in the drugs as levomepromazine hydrochloride or levomepromazine maleate. These are faint yellowish crystalline powders. Levomepromazine maleate is sparingly soluble in water and … Levomepromazine
Products Lumateperone was approved in the United States in 2019 in capsule form (Caplyta). Structure and properties Lumateperone (C24H28FN3O, Mr = 393.5 g/mol) is present in the drug as lumate perontosylate. Like haloperidol (Haldol), for example, it belongs to the butyrophenone group. Effects Lumateperone has antipsychotic and antidepressant properties. Effects are attributed to antagonism at … Lumateperon
Products Lurasidone is commercially available in the form of film-coated tablets (Latuda). It has been approved in many countries since 2013. In the United States, it was registered as early as 2010. Structure and properties Lurasidone (C28H36N4O2S, Mr = 492.7 g/mol) belongs to the benzoisothiazoles. It exists as a white powder that is sparingly soluble … Lurasidon
