Products Perphenazine was commercially available in the form of film-coated tablets (Trilafon). It was approved in many countries in 1957 and went out of commerce on 3/31/2013. Structure and properties Perphenazine (C21H26ClN3OS, Mr = 403.9 g/mol) is a piperidine derivative of phenothiazine. It exists as a white to yellowish white crystalline powder that is practically … Perphenazine
Products Asenapine is commercially available in the form of sublingual tablets (Sycrest). It was approved in many countries in 2012. In the United States, it has been registered since 2009. Structure and properties Asenapine (C17H16ClNO, Mr = 285.8 g/mol) is present in the drug as asenapine maleate. It belongs to the class of dibenzooxepin pyrroles. … Asenapine
Effects Diphenylbutylpiperidines are antidopaminergic, antipsychotic, and antiemetic. Mechanism of action Dopamine antagonists Indications Clinical pictures of the schizophrenic type. Structure and properties Derivatives of diphenylbutylpiperidine. Active ingredients Penfluridol (Semap, off label). Fluspirilen (IMPA, D) Pimozide (out of commerce)
Products Droperidol is commercially available as a solution for injection (Droperidol Sintetica). It has been approved in many countries since 2006. Structure and properties Droperidol (C22H22FN3O2, Mr = 379.4 g/mol) structurally belongs to the butyrphenones and exists as a white powder that is practically insoluble in water. It is a benzimidazolinone derivative. Effects Droperidol (ATC … Droperidol
Products Haloperidol is commercially available as tablets, drops (Haldol), and as a solution for injection (Haldol, Haldol decanoas). It has been approved in many countries since 1960. Structure and properties Haloperidol (C21H23ClFNO2, Mr = 375.9 g/mol) is a derivative of pethidine, which is itself derived from atropine. It has structural similarity to loperamide. Haloperidol exists … Haloperidol
Products There are no drugs containing bromperidol on the market in many countries. Structure and properties Bromperidol (C21H23BrFNO2, Mr = 420.3 g/mol) exists as a white powder that is practically insoluble in water. It is identical to haloperidol but is brominated instead of chlorinated. Bromperidol is a butyrphenone derivative. Bromperidol decanoate (depot injection) is also … Bromperidol
Products Tiapride is commercially available in tablet form (Tiapridal). It has been approved in many countries since 1981. Structure and properties Tiapride (C15H24N2O4S, Mr = 328.4 g/mol) is present in drugs as tiapride hydrochloride, a white crystalline powder that is very soluble in water. It is an orthomethoxy-substituted benzamide. Effects Tiapride (ATC N05AL03) has antidopaminergic … Tiapride
Products Loxapine has been approved in the EU as a powder for inhalation since 2013 (Adasuve). It was registered in many countries in 2016. Capsules are additionally available in the United States. Structure and properties Loxapine (C18H18ClN3O, Mr = 327.8 g/mol) is present in drugs as loxapine succinate. It is a piperazine derivative and structurally … Loxapine
Products Paliperidone is commercially available as sustained-release tablets (Invega, generic) and as a sustained-release suspension for intramuscular injection (Xeplion, Trevicta, generic). It has been approved in many countries since 2008. Structure and properties Paliperidone (C23H27FN4O3, Mr = 426.5 g/mol) exists as a racemate and is practically insoluble in water. It belongs to the group of … Paliperidone
Products Fluphenazine was approved in many countries in 1971 and was commercially available as a solution for injection (Dapotum D), among other products. It has since been withdrawn from the market. Structure and properties Fluphenazine (C22H26F3N3OS, Mr = 437.5 g/mol) Effects Fluphenazine (ATC N05AB02) has antipsychotic properties. Indications Psychiatric disorders
Products Flupentixol is commercially available as film-coated tablets and as a solution for injection (Fluanxol). A fixed combination with melitracene is also available (Deanxit). The drug has been approved in many countries since 1967. See also under melitracene and flupentixol. Structure and properties Flupentixol (C23H25F3N2OS, Mr = 434.5 g/mol) is a thioxanthene derivative and a … Flupentixol
Products Amisulpride is commercially available as tablets, film-coated tablets, and a drinkable solution (Solian, generic). It has been approved in many countries since 1998. Structure and properties Amisulpride (C17H27N3O4S, Mr = 369.5 g/mol) is a substituted benzamide and a racemate. It exists as a white crystalline powder that is practically insoluble in water. Effects Amisulpride … Amisulpride
