Products Thiethylperazine was commercially available in the form of dragées, as a solution for injection, and as suppositories (Torecan, Novartis). It had been approved in many countries since 1960. The suppositories went out of circulation in 2010 due to lack of demand. The other dosage forms were withdrawn from the market in 2014. Structure and … Thiethylperazine
Products Thioridazine has been off the market in many countries since 2005 because of cardiac risks. Melleril and Mellerette tablets are out of commerce. In Germany and other countries, thioridazine remains on the market. Structure and properties Thioridazine (C21H26N2S2, Mr = 370.6 g/mol) is a phenothiazine derivative with a piperidinyl alkyl side chain. In drugs, … Thioridazine
Products Promazine is commercially available in the form of dragées (Prazine). It has been approved in many countries since 1957. Structure and properties Promazine (C17H20N2S, Mr = 284.4 g/mol) is present in drugs as promazine hydrochloride, a white crystalline powder that is very soluble in water. It is a dimethylamine derivative of phenothiazine and structurally … Promazine
Products Perphenazine was commercially available in the form of film-coated tablets (Trilafon). It was approved in many countries in 1957 and went out of commerce on 3/31/2013. Structure and properties Perphenazine (C21H26ClN3OS, Mr = 403.9 g/mol) is a piperidine derivative of phenothiazine. It exists as a white to yellowish white crystalline powder that is practically … Perphenazine
Products Fluphenazine was approved in many countries in 1971 and was commercially available as a solution for injection (Dapotum D), among other products. It has since been withdrawn from the market. Structure and properties Fluphenazine (C22H26F3N3OS, Mr = 437.5 g/mol) Effects Fluphenazine (ATC N05AB02) has antipsychotic properties. Indications Psychiatric disorders
Products Chlorpromazine was commercially available in various oral and parenteral dosage forms (e.g., Chlorazine, Thorazine, Largactil, Megaphene). It was first used in the 1950s as one of the first synthetic antipsychotics. Today, it is no longer a registered drug in many countries. In some countries, chlorpromazine is still on the market. Structure and properties Chlorpromazine … Chlorpromazine
Products Levomepromazine is commercially available as film-coated tablets and oral solution (Nozinan). It has been approved in many countries since 1958. Structure and properties Levomepromazine (C19H24N2OS, Mr = 328.5 g/mol) is present in the drugs as levomepromazine hydrochloride or levomepromazine maleate. These are faint yellowish crystalline powders. Levomepromazine maleate is sparingly soluble in water and … Levomepromazine