The normal prostate gland is created intrauterine (“inside the uterus“) at 12 weeks of gestation, but then remains rudimentary until it continues to develop at puberty under the influence of androgens. Endogenous prostate-related hormones are produced 90% in the testis and 10% in the adrenal cortex. Testosterone is the most important androgen. It is produced … Prostate Cancer: Physiology
Clinically, a distinction is made between the left and right lateral lobes, which are separated by the medial (“middle”) sulcus (Latin: central furrow), which can be palpated rectally (“through the rectum“), and the middle lobe, which forms the posterior wall, so to speak, of the prostatic urethra (part of the urethra that passes through the … Prostate Cancer: Anatomy
Subsequent statements are based on the current S3 guideline unless otherwise noted. Recurrence estimated to be locally confined In patients with PSA recurrence and favorable prognostic criteria, wait-and-see is an option. HIFU therapy (high-intensity focused ultrasound; High-Intensity Focused Ultrasound, HIFU) can be used for the therapy of histologically (fine tissue) confirmed isolated local recurrence (local … Prostate Cancer: Recurrent Therapy
General measures Nicotine restriction (refraining from tobacco use) – smoking increases not only the risk of tumor progression (progression of tumor disease) and cancer-related mortality (death rate) but also toxicity to external beam radiation therapy (radiatio) Alcohol restriction (abstaining from alcohol). Normal weight to strive for or maintain! Determination of BMI (body mass index, body … Prostate Cancer: Therapy
