1st order laboratory parameters – obligatory laboratory tests.
- Small blood count
- Inflammatory parameters – CRP (C-reactive protein).
- Electrolytes – sodium, potassium, calcium, etc.
- Blood gas analysis (BGA) with lactate determination.
- Serum globulins
- Serum albumin – important protein (protein) [albumin ↓, as a sign of liver synthesis disorder].
- Liver parameters – alanine aminotransferase (ALT, GPT), aspartate aminotransferase (AST, GOT), glutamate dehydrogenase (GLDH) and gamma-glutamyl transferase (gamma-GT, GGT), alkaline phosphatase, bilirubin.
- CHE (cholinesterase) [CHE ↓, as a sign of liver synthesis disorder]
- Ammonia – liver detoxification performance parameter [ammonia ↑]
- Renal parameters – urea, creatinine, cystatin C or creatinine clearance, if necessary.
- Coagulation parameters – PTT, Quick
Laboratory parameters 2nd order – depending on the results of the history, physical examination and mandatory laboratory parameters – for differential diagnostic clarification.
- Histopathological (fine tissue) examination of a liver puncture (liver biopsy).
- Virus diagnostics (HAV, HBV, HCV, HEV, HIV, HSV, CMV, EHV, VZV).
- Drug levels – if intoxication (poisoning) with paracetamol / acetaminophen is suspected.
- Toxicological screening – amphetamines, barbiturates, benzodiazepines, cannabinoids, ecstasy, cocaine, metamphetamines, opiates, tricyclic antidepressants, etc.).
- Genetic diagnostics or determination of: Caeruloplasmin, ferritin, transferrin saturation; alpha1-antitrypsin – if Wilson’s disease or alpha-1-antitrypsin deficiency is suspected.
- ANA, SMA, AMA, ANCA – if autoimmune disease is suspected.
- Pregnancy test (quantitative HCG).
