Products
To date, hydrocortisone acetate is the only glucocorticoid approved for self-medication in many countries and is available without a doctor’s prescription. A cream (Dermacalm with dexpanthenol) and a hydrocream (Sanadermil) are available. Hydrocortisone was the first dermocorticoid and was introduced in the 1950s.
Structure and properties
Hydrocortisone acetate (C23H32O6, Mr = 404.5 g/mol) is an acetylated hydrocortisone (cortisol). It exists as a white crystalline powder that is practically insoluble in water.
Effects
Hydrocortisone acetate (ATC D07AA02) has anti-inflammatory, antiallergic, immunosuppressive, and antipruritic properties. It is a weakly potent glucocorticoid. The effects are due to binding to glucocorticoid receptors.
Indications
For the treatment of noninfectious inflammatory skin conditions, for example, mild eczema, skin irritation, skin redness, small-area sunburn, and insect bites.
Dosage
According to the professional information. The drug is applied thinly once or twice a day. The duration of treatment should not exceed two weeks.
Contraindications
- Hypersensitivity
- Infectious diseases of the skin
- Rosacea
- Perioral dermatitis
- After vaccinations
- In the area of the eyes
- On open wounds
Full precautions can be found in the drug label.
Interactions
Drug-drug interactions are not known.
Adverse effects
Possible adverse effects include local skin reactions such as itching, burning, or skin irritation. However, when used as directed, hydrocortisone acetate is usually well tolerated. If, on the other hand, it is used for weeks, in high doses, and under occlusion, skin damage typical of glucocorticoids may occur (e.g., skin atrophy, stretch marks, telangiectasia).
