Products
Levodropropizine is commercially available in the form of drops and as a syrup (e.g., Quimbo). The drug is not registered in many countries.
Structure and properties
Levodropropizine (C13H20N2O2, Mr = 236.3 g/mol) is a white crystalline powder. It is the -enantiomer of dropropizine (Larylin) and a phenylpiperazine propane derivative. Levodropropizine is considered more pharmacologically active than the racemate.
Effects
Levodropropizine (ATC R05DB27) is thought to have antitussive properties attributed to its peripheral action on the tracheobronchial tree. Based on experiments, inhibition of afferent C-fibers is reported as a possible mechanism of action. Antihistamine and vasodilatory effects are also described in the literature ( adverse effect low blood pressure). Levodropropizine has structural similarities to some antihistamines such as cetirizine.
Indications
For symptomatic treatment of nonproductive irritable cough.
Dosage
According to the SmPC. Levodropropizine is taken up to 3 times daily between meals because of its short half-life.
Contraindications
Levodropropizine should not be used hypersensitivity, productive cough, decreased mucociliary function, severely impaired liver function, and in children younger than 2 years of age. For complete precautions, see the drug label.
Interactions
Concurrent use of sedatives and alcohol should be avoided as a precaution.
Adverse effects
Rarely, skin reactions, hypersensitivity reactions, indigestion, fatigue, drowsiness, palpitations, low blood pressure, difficulty breathing, and muscle weakness have been reported. The hypersensitivity reactions are due in part to the preservative contained in the drug.