Olfactory Disorders (Dysosmia): Drug Therapy

Therapeutic target

Improvement of symptomatology

Therapy recommendations

The following agents are indicated for sinunasal-related (sinus-related) olfactory disorders:

  • Mucosal care with nasal oil, ointment, saline spray.
  • Topical (“topical”) glucocorticoid nasal spray (into the olfactory cleft), unspecified
  • See also under “Other therapy.”

The following agents are indicated for postviral (after a viral infection), posttraumatic (after injury), and idiopathic olfactory disorders (with no known cause):

  • Daily olfactory training with eucalyptus, clove, rose and lemon scents (morning and evening, for about 1 year).

Other tips

  • Glucorticoid therapy was most successful in patients who developed anemia or hyposmia following an upper respiratory tract infection. In this group, the cure rate was 59.6%. In olfactory disorders following head trauma, therapy helped in only 12.5% of cases. It was also shown that an early start, ie, with only a few weeks of existing olfactory dysfunction, significantly better cure rates could achieve.
  • There is a small body of evidence that topical glucocorticoids improve olfaction (especially in seasonal allergic rhinitis)