Therapeutic goals or recommendations
- In exocrine pancreatic insufficiency (disease of the pancreas associated with insufficient production of digestive enzymes): Substitution (“replacement”) of the missing enzymes (see below pancreatic enzymes).
- Endocrine pancreatic insufficiency (disease of the pancreas associated with insufficient production of hormones, specifically insulin and glucagon): Achieving stable glucose controlThe endocrine pancreatic insufficiency is treated like type 1 diabetes mellitus [see under type 1 diabetes mellitus].Caveat (Warning!): hypoglycemias (low blood sugar).
- See also under “Further therapy“.
| BG preprandial (fasting) | <100 mg/dl (<5.5 mmol/l) |
| BG 1-2 h postprandial (after meal). | < 180 mg/dl (< 10 mmol/l) |
| HbA1c | <6.5% (in D. m. Type 1 only lower if no frequent hypoglycemias/ hypoglycemic episodes). |
Pancreatic enzymes
| Active substances | Dosage | Special features |
| Pancreatin |
Take during or immediately after a meal to ensure good mixing with food in the stomach |
Mostly porcine pancreatin indications (indicated) for:
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