2nd order laboratory parameters – depending on the results of the medical history, physical examination, etc. – for differential diagnostic clarification
- Beta-amyloid and tau protein (in cerebrospinal fluid) [see below, “Further notes”].
- Parkinson’s disease genetic test – test that can be performed when familial Parkinson’s disease is suspected; currently, more than 10 genes are known whose alteration can lead to Parkinson’s disease; in Germany, these include primarily LRRK2 (gene locus PARK8) and Parkin (gene locus PARK2); see also “Causes”/Biographic CausesIndications: Genetic counseling may be offered at the patient’s request if.
- At least 2 1st-degree relatives have Parkinson’s disease, or
- In the case of an isolated-appearing Parkinson’s syndrome, there is evidence of disease manifestation before the age of 45 years. (Expert consensus)If a monogenic etiology is suspected, testing of appropriate genes may be considered. (Expert consensus)
- Uric acid – as a biomarker for Parkinson’s disease [elevated levels are associated with a decreased risk of Parkinson’s disease].
- TPHA screening test – pathogen screening test for suspected syphilis (lues).
- Copper in serum
- Small blood count
- Coagulation parameters such as Quick or INR
Further notes
- Routine CSF findings and extended routine findings are usually unremarkable in patients with idiopathic Parkinson’s disease (IPS). CSF analysis cannot confirm IPS at this time. (Expert Consensus)
- For cognitive impairment in patients with IPS, CSF analysis for routine parameters, as well as tau protein and β-amyloid, may be considered. In atypical courses, routine CSF analysis may be performed, depending on differential diagnostic considerations. (Expert consensus)
- Alpha-synuclein deposits in the skin (biopsy).
