Congenital malformations, deformities, and chromosomal abnormalities (Q00-Q99).
- Hymenal atresia – lack of opening of the hymen.
- Laurence-Moon-Biedl-Bardet syndrome (LMBBS) – rare genetic disorder with autosomal recessive inheritance; according to clinical symptoms is divided into:
- Laurence-Moon syndrome (without polydactyly, i.e., without the appearance of supernumerary fingers or toes, and obesity, but with paraplegia (paraplegia) and muscle hypotonia/reduced muscle tone) and
- Bardet-Biedl syndrome (with polydactyly, obesity and peculiarities of the kidneys).
- Mayer-von-Rokitansky-Küster-Hauser syndrome (MRKH syndrome or Küster-Hauser syndrome) – genetic disorder with autosomal dominant inheritance; congenital malformation of the female genitalia due to inhibition malformation of the Müller ducts in the second embryonic month. Ovarian function (estrogen and progestin synthesis) is not impaired, allowing normal development of secondary sexual characteristics.
- Vaginal aplasia – embryonically not created vagina.
Endocrine, nutritional and metabolic diseases (E00-E90).
- Obesity (overweight)
- Adrenogenital syndrome (AGS) – autosomal recessive inherited metabolic disease characterized by disorders of hormone synthesis in the adrenal cortex. These disorders lead to a deficiency of aldosterone and cortisol.comes
- Hyperandrogenemia – increase in male sex hormones in the blood.
- Hyperprolactinemia – increase in prolactin levels in the blood, this can lead to, among other things, follicle maturation disorders (egg maturation disorders).
- Hypothyroidism (underactive thyroid gland).
- Kallmann syndrome (synonym: olfactogenital syndrome) – genetic disorder that can occur sporadically, as well as inherited autosomal dominant, autosomal recessive and X-linked recessive; symptom complex of hypo- or Anosmia (decreased to absent sense of smell) in conjunction with testicular or ovarian hypoplasia (defective development of the testis or ovaries, respectively); prevalence (disease frequency) in males 1: 10,000 and in females 1: 50,000.
- Cushing’s disease – disease in which too much ACTH is produced by the pituitary gland, resulting in increased stimulation of the adrenal cortex and, as a consequence, excessive cortisol production.
- Sheehan syndrome – acquired anterior pituitary insufficiency (HVL insufficiency; insufficient hormone production by the anterior lobe of the pituitary gland (pituitary gland)) due to postpartum pituitary necrosis (death of pituitary gland tissue after birth)
- Premature ovarian exhaustion – exhaustion of the ovaries with progressive follicular atresia (non-formation of follicles).
Neoplasms – tumor diseases (C00-D48).
- Brenner tumor – usually benign tumor of the ovary (ovary) that releases estrogens (female sex hormones).
- Granulosatheca cell tumors – malignant (malignant) tumor of the ovary, which forms estrogens (female sex hormone).
- Pituitary tumors – tumors of the pituitary gland (pituitary gland).
- Hypothalamus tumors – tumors of the diencephalon.
- Krukenberg tumor (fibrosarcoma ovarii mucocellulare carcinomatodes) – ovarian metastases of gastrointestinal carcinoma (histology: mucus-filled signet ring cells → drip metastases of primary gastric carcinoma/stomach cancer).
- Mucinous cystadenomas – benign tumor arising from glandular tissue and producing mucus.
- Cystic teratomas – tumor arising from the gonads, which is also called a miracle tumor; it can involve various tissues of the body such as teeth or hair
Psyche – nervous system (F00-F99; G00-G99).
- Anorexia nervosa (anorexia nervosa)
- Inflammation in the area of the hypothalamus.
- Psychogenic reaction such as after severe personal or other disasters.
Genitourinary system (kidneys, urinary tract – reproductive organs) (N00-N99).
- Asherman syndrome – loss of the endometrium (lining of the uterus) due to severe inflammation or trauma.
- Post-pill amenorrhea – absence of menstruation after stopping the use of contraceptives (birth control pills).
- Ovarian hypoplasia – underdevelopment of the ovaries due to various diseases such as Turner syndrome (gonadal dysgenesis).
Further
- Competitive sports
Medication
- Anabolic steroids
- Androgens – male sex hormones
- Ciclosporin (cyclosporin A) – immunosuppressant; drug prescribed primarily after organ transplantation to prevent organ rejection by the body’s own immune system.
- Diazoxide – drug used as an antihypertensive (high blood pressure drug).
- Minoxidil – drug which acts vasodilator (vasodilator); used in the therapy of hypertension (high blood pressure) and alopecia (baldness).
- Phenytoin (anti-epileptic) – drug used in epilepsy.
Other possible differential diagnoses
- Gravidity (pregnancy)
- Lactation period (breastfeeding)
- Postmenopause – time after menopause.
- Prepuberty – time before the first menstrual period.
