To prevent Quincke’s edema (angioedema), attention must be paid to reducing individual risk factors.
Risk factors
- Physical – pressure, cold, light, etc.
- Psychological stress situations
Medication
- ACE inhibitors [>50% of cases with severe angioedema; trigger of acute HAE attacks]
- Acetylsalicylic acid (ASA).
- Angiotensin receptor neprilysin antagonists (ARNI) – dual drug combination: sacubitril/valsartan.
- AT1 antagonists (angiotensin II receptor subtype 1 antagonists, AT1 receptor antagonists, AT1 blockers, angiotensin receptor blockers, “sartans“) [rare].
- Hormone replacement therapy (HRT)
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Estrogen-containing contraceptives – these can cause attacks to cluster [trigger acute HAE attacks].
- X-ray contrast media (as an immediate response).
