Interactions of selenium with other micronutrients (vital substances):
Iodine
Selenium deficiency can exacerbate the symptoms of iodine deficiency. Iodine is essential for the synthesis of thyroid hormone. At the same time, selenium-containing enzymes – iodothyronine deiodinases -, are needed for the conversion of thyroxine (T4) to the biologically active thyroid hormone triiodothyroxine (T3). Supplemental selenium administration in elderly subjects decreased the amount of T4 in the blood and resulted in increased deiodinase activity, leading to increased conversion to T3.
Selenium
Selenium, as an essential component of glutathione peroxidases and thioredoxin reductase, arguably affects every micronutrient that influences the oxidative balance of the cell.
Selenium, as a gluthathione peroxidase, appears to support the activity of vitamin E (alpha-tocopherol) in protecting against lipid peroxidation.Studies in animals show that selenium and vitamin E can partially substitute for each other, and selenium can prevent some of the oxidative stress and its consequences caused by vitamin E deficiency.Thioredoxin reductase catalyzes the regeneration of vitamin C, thus maintaining its antioxidant function.