Products
Temazepam is commercially available in capsule form (Normison). It has been approved in many countries since 1983.
Structure and properties
Temazepam (C16H13ClN2O2, Mr = 300.7 g/mol) is a white crystalline powder that is practically insoluble in water. It is present in drugs as a racemate (hydroxyl group). Temazepam belongs to the 5-aryl-1,4-benzodiazepines.
Effects
Temazepam (ATC N05CD07) has antianxiety, sedative, sleep-inducing, anticonvulsant, and muscle relaxant properties.
Indications
For short-term treatment of sleep disorders in adults. For premedication in adults.
Abuse
Temazepam, like all benzodiazepines, can be abused as a sedative and relaxant intoxicant.
Dosage
The drug is taken immediately, no more than 30 minutes before bedtime. The duration of therapy should be kept as short as possible and should not exceed 4 weeks.
Contraindications
- Hypersensitivity
- Myasthenia gravis
- Severe respiratory insufficiency
- Sleep apnea
Full precautions can be found in the drug label.
Interactions
Centrally depressant drugs and substances, such as alcohol, intoxicants, psychotropic drugs, sleeping pills, antianxiety agents, opioids, antiepileptic drugs, and antihistamines, may potentiate the depressant effects of temazepam.
Adverse effects
Occasionally, digestive problems, muscle weakness, gait disturbances, decreased libido, skin reactions, visual disturbances, drowsiness, numbness, reduced responsiveness, confusional states, fatigue, headache, dizziness may occur. Anterograde amnesia, depression, and alteration of blood counts are rare. Temazepam, like other benzodiazepines, may be addictive, and tolerance may develop with prolonged treatment.
