Therapy during pregnancy | Therapy of ulcerative colitis

Therapy during pregnancy

In a therapy during pregnancy, a balance must be found between minimal medication and adequate treatment of ulcerative colitis. If mesalazine or corticosteroids are taken in remission therapy, they can normally be taken in the same dosage during pregnancy. An acute relapse represents a much greater risk for the unborn child and should be induced to remission as soon as possible during pregnancy using the classic treatment regimen.The medication should be discussed with the treating gastroenterologist and the gynecologist before the desire to have children and adjusted if necessary.

Azathioprine should be given during pregnancy only for special indications and with caution. Other immunosuppressive drugs such as Ciclosporin A or Tacrolimus should not be given during pregnancy as negative effects have been observed in animal experiments. In clinical practice, patients with transplantations on the other hand are known to become pregnant without complications when taking these drugs. TNF-alpha inhibitors such as Remicarde® and Humira® are strictly contraindicated during pregnancy.