Products Most ACE inhibitors are commercially available in the form of tablets and film-coated tablets. The first agent from this group to be approved was captopril, in many countries in 1980. ACE inhibitors are often combined with the thiazide diuretic hydrochlorothiazide (HCT) fix. Structure and properties ACE inhibitors are peptidomimetics derived from peptides found in … ACE Inhibitors List, Effects, Side Effects
Effects Reverse transcriptase inhibitors (ATC J05AF) have antiviral properties against HIV. The effects are due to inhibition of the viral enzyme reverse transcriptase, which transcribes viral RNA into DNA and is important for viral replication. Structure and properties Within the drug group, two distinct classes are distinguished. The so-called nucleoside reverse transcriptase inhibitors, abbreviated NRTIs, … Reverse Transcriptase Inhibitors (HIV)
Products Bextra film-coated tablets are no longer on the market in many countries. Approval was withdrawn in April 2005 because rare severe skin reactions had occurred during treatment (see below). Structure and properties Valdecoxib (C16H14N2O3S, Mr = 314.4 g/mol) is a phenylisoxazole and a benzenesulfonamide derivative. It has a V-shaped structure with which it binds … Valdecoxib
Products COX-2 inhibitors (coxibe) are commercially available in the form of film-coated tablets and capsules. The first representatives from this group to be approved in many countries were celecoxib (Celebrex, USA: 1998) and rofecoxib (Vioxx, off label) in 1999. At that time, they rapidly developed into blockbuster drugs. However, due to adverse effects, several drugs … COX-2 Inhibitor
Definition Amines are organic molecules containing nitrogen (N) atoms bonded to carbon or hydrogen atoms. They are formally derived from ammonia, in which hydrogen atoms have been replaced by carbon atoms. Primary amines: 1 carbon atom Secondary amines: 2 carbon atoms Tertiary amines: 3 carbon atoms The functional group is called the amino group, for … Amines
Products Enzymes are commercially available as drugs in the form of tablets, lozenges, capsules, as well as injection and infusion preparations, among others. Many products are subject to prescription, but there are also some agents which are released for the OTC market. Structure and properties Therapeutic enzymes are usually proteins, i.e. polymers of amino acids, … Therapeutic Enzymes
Products Tavaborole was approved in the United States in 2014 as a solution for external use (Kerydin). The drug is not currently registered in many countries. Structure and properties Tavaborole (C7H6BFO2, Mr = 151.9 g/mol) exists as a white powder that is sparingly soluble in water. It is an organic boron compound belonging to the … Tavaborol
Products Direct oral anticoagulants (abbreviation: DOAKs) are commercially available in the form of film-coated tablets and capsules. By definition, they are oral drugs. Some representatives of the corresponding drug groups are also available as infusion preparations. Rivaroxaban (Xarelto) and dabigatran (Pradaxa) were the first active ingredients to be approved in 2008. The DOAKs were developed … DOAK
Products Direct factor Xa inhibitors are commercially available in the form of film-coated tablets and capsules. In 2008, rivaroxaban (Xarelto) was the first agent in this group to be approved in many countries and in the EU. Today, there are other drugs on the market, which are listed below. Like thrombin inhibitors, these active ingredients … Factor Xa Inhibitors
Products Celecoxib is commercially available in capsule form (Celebrex, generic). It was approved in many countries in 1999 as the first member of the selective COX-2 inhibitors. Generic versions went on sale in 2014. Structure and properties Celecoxib (C17H14F3N3O2S, Mr = 381.37 g/mol) is a benzenesulfonamide and a substituted diaryl pyrazole. It has a V-shaped … Celecoxib
Products Most HIV protease inhibitors are commercially available in tablet or capsule form. In addition, a few liquid dosage forms are available for ingestion. Saquinavir (Invirase) was the first to be lanicized in 1995. Structure and properties The first HIV protease inhibitors were modeled on the natural peptide substrate of the HIV protease. The protease … HIV Protease Inhibitor
Products Rofecoxib was approved in many countries in 1999 in tablet and suspension form (Vioxx). It was withdrawn from the market again in late September 2004 because of adverse effects and is no longer available. Structure and properties Rofecoxib (C17H14O4S, Mr = 314.4 g/mol) is a methyl sulfone and a furanone derivative. It has a … Rofecoxib
