Products Medicines containing zipeprol are no longer on the market in many countries. Mirsol is no longer available. Zipeprol is classified as a narcotic. Structure and properties Zipeprol (C23H32N2O3, Mr = 384.5 g/mol) is a disubstituted piperazine derivative with a non-opioid structure. Effects Zipeprol (ATC R05DB15) has antitussive properties. In addition, anticholinergic, antihistamine, local anesthetic, … Zipeprol
Products Datura extracts are hardly used pharmaceutically today. Alternative medicine preparations such as homeopathics and the pure ingredients such as atropine and scopolamine are an exception. Stem plant Datura L. of the nightshade family (Solanaceae). Medicinal drug Stramonium leaves (Stramonii folium) are used as a medicinal raw material, the dried leaves or from the dried … Datura: Medicinal Uses
Products Biperiden is commercially available as tablets, sustained-release tablets, and a solution for injection (Akineton, Akineton retard). It has been approved in many countries since 1958. Structure and properties Biperiden (C21H29NO, Mr = 311.46 g/mol) is present in drugs as biperidene hydrochloride, a white crystalline powder that is sparingly soluble in water. It is a … Biperides
Products Revefenacin was approved in the United States in 2018 as a monodose inhalation solution (Yupelri). The active ingredient belongs to the LAMA group. Structure and properties Revefenacin (C35H43N5O4, Mr = 597.8 g/mol) exists as a white crystalline powder and is sparingly soluble in water. It has an active metabolite formed by hydrolysis. Effects Revefenacin … Revefenacin
Withdrawal from the market Rhinathiol Promethazine (Sanofi-Aventis Suisse SA, category C) contained a combination of the sedative antihistamine promethazine and the expectorant mucolytic carbocisteine. According to the package insert, the syrup could be taken for both productive cough and irritable cough (1). It was frequently used in children. The drug was withdrawn from the market … Rhinathiol Promethazine
Products The fixed combination Deanxit with the two active ingredients melitracene and flupentixol is commercially available in many countries in the form of film-coated tablets. The drug has been approved since 1973, initially as dragées. The marketing authorization holder is the Danish company Lundbeck. Structure and properties The active ingredients are present in the drug … Melitracene and Flupentixol
Products Pethidine is commercially available as a solution for injection. It has been approved in many countries since 1947. The drug is subject to strict control as a narcotic and is available only by prescription. Structure and properties Pethidine (C15H21NO2, Mr = 247.3 g/mol) is a phenylpiperidine derivative. In pharmaceuticals, it is present as pethidine … Pethidine
Products Solifenacin is commercially available in the form of film-coated tablets (Vesicare, generics). It has been approved in many countries since 2006. Structure and properties Solifenacin (C23H26N2O2, Mr = 362.5 g/mol) is a tertiary amine and a phenylquinoline derivative that has structural similarities to atropine. It is present in drugs as (1)-(3)-solifenacin succinate, a white … Solifenacin
Products Cyclobenzaprine is commercially available in the United States and elsewhere in the form of film-coated tablets. No finished drug products containing cyclobenzaprine are currently registered in many countries. Structure and properties Cyclobenzaprine (C20H21N, Mr = 275.4 g/mol) is present in drugs as cyclobenzaprine hydrochloride, a white crystalline powder that is soluble in water. It … Cyclobenzaprine
Products Cyclopentolate is commercially available in the form of eye drops (cyclogyl). It has been approved in many countries since 1968. Structure and properties Cyclopentolate (C17H25NO3, Mr = 291.4 g/mol) is present in drugs as cyclopentolate hydrochloride, a white crystalline powder. It is a racemate and a derivative of atropine, which is used for the … Cyclopentolate
Products In many countries, drugs containing promethazine are currently no longer on the market. The last product to be withdrawn from the market was Rhinathiol promethazine with the expectorant carbocisteine on January 31, 2009. However, medicines are still available in many countries. The original drug is Phenergan. Promethazine was developed in the 1940s at Rhône-Poulenc, … Promethazine
Products Propiverine was approved in many countries in 2020 in the form of modified-release hard capsules (Mictonorm). Later, coated tablets were also registered (Mictonet). This is an older active ingredient that was available earlier in Germany, for example. Structure and properties Propiverine (C23H29NO3, Mr = 367.5 g/mol) is present in drugs as propiverine hydrochloride. Active … Propiverine
