Intensive Care: Treatment, Effects & Risks

Intensive care medicine deals with the diagnosis and treatment of life-threatening diseases and conditions. It is closely related to emergency medicine, as intensive medical measures are used to maintain vital functions. The primary goal is to preserve the life of the patient, with the diagnosis being secondary for the time being. What is intensive care … Intensive Care: Treatment, Effects & Risks

Dimercaptopropanesulfonic Acid (DMPS)

Products Dimercaptopropanesulfonic acid is commercially available in some countries as a solution for injection and in capsule form (Dimaval). Structure and properties Dimercaptopropanesulfonic acid or DMPS (C3H8O3S3, Mr = 188.3 g/mol) exists in the drug as a sodium salt and monohydrate. It is a dithiol and a sulfonic acid structurally related to dimercaprol. Effects DMPS … Dimercaptopropanesulfonic Acid (DMPS)

Methanol

Products Methanol is available as a chemical in stores and, for example, in pharmacies and drugstores. Structure and properties Methanol (CH3OH, Mr = 32.0 g/mol) exists as a colorless liquid with an alcohol-like odor that is miscible with water. It is harmful to health and highly flammable. Methanol vapors can form an explosive mixture with … Methanol

Andexanet Alfa

Products Andexanet alfa was approved in the United States in 2018, in the EU in 2019, and in many countries in 2020 as a powder for the preparation of an infusion solution (Ondexxya). Structure and properties Andexanet alfa is a recombinant, modified, and enzymatically inactive factor Xa. The drug is produced by biotechnological methods. Effects … Andexanet Alfa

Fomepizole

Products Fomepizole is commercially available as an injection or infusion solution. In many countries, the drug is not registered, but it is among the official antidotes of the FOPH and can be imported from abroad. Structure and properties Fomepizole (C4H6N2, Mr = 82.1 g/mol) is 4-methylpyrazole, a clear to yellow liquid that can exist as … Fomepizole

Brodifacoum

Products Brodifacoum is found in mouse and rat poisons. Structure and properties Brodifacoum (C31H23BrO3, Mr = 523.4 g/mol) is a brominated coumarin (4-hydroxycoumarin) and warfarin derivative. It was developed because resistance occurred with the use of warfarin. Brodifacoum exists as an off-white to beige powder that is sparingly soluble in water. The melting point is … Brodifacoum

Amyl Nitrite

Products Amyl nitrite is commercially available in the form of ampoules (Amyle Nitrite Inhalant USP). The product, available in many countries, is imported from abroad and is not officially approved as a drug. Amyl nitrite is included in the Federal Office of Public Health‘s antidote list and must be stocked in hospitals for the treatment … Amyl Nitrite

Difenacoum

Products Difenacoum is found in mouse and rat poisons (e.g., Gesal Protect rat and mouse bait). It has been available since the 1970s. Structure and properties Difenacoum is a (C31H24O3, Mr = 444.5 g/mol) is a 4-hydroxycoumarin, warfarin, and biphenyl derivative. It was developed to overcome resistance to warfarin (“superwarfarin”). Difenacoum is structurally closely related … Difenacoum

Intravenous Injection

Definition In an intravenous injection, a small volume of a drug is administered into a vein using a needle and syringe. The active ingredients disperse into the bloodstream and reach their site of action. For repeated administration, venous access is established with a peripheral venous catheter. Larger volumes can be infused during an intravenous infusion. … Intravenous Injection

Phytomenadione

Products Phytomenadione is commercially available as a solution for injection and a solution for oral use (Konakion MM). It has been approved in many countries since 1987. Structure and properties Phytomenadione (C31H46O2, Mr = 450.7 g/mol) is a mixture of -phytomenadione, -phytomenadione, and -epoxyphytomenadione. It exists as a clear, intense yellow, viscous, oily liquid and … Phytomenadione

DOAK

Products Direct oral anticoagulants (abbreviation: DOAKs) are commercially available in the form of film-coated tablets and capsules. By definition, they are oral drugs. Some representatives of the corresponding drug groups are also available as infusion preparations. Rivaroxaban (Xarelto) and dabigatran (Pradaxa) were the first active ingredients to be approved in 2008. The DOAKs were developed … DOAK