Products Cyclandelate was commercially available in many countries in the form of dragées (Cyclandelat Streuli). It was approved in 1973 and went out of commerce in 2012. Structure and properties Cyclandelate (C17H24O3, Mr = 276.4 g/mol) Effects Cyclandelate (ATC C04AX01) has vasodilator properties. It has a direct papaverine-like effect on smooth muscle, particularly that of … Cyclandelate
Products Naftidrofuryl is commercially available in tablet form (Praxilene). It has been approved in many countries since 1982. Structure and properties Naftidrofuryl (C24H33NO3, Mr = 383.5 g/mol) is present in drugs as naftidrofuryl hydrogen oxalate, a white powder that is readily soluble in water. It is a mixture of 4 stereoisomers. Effects Naftidrofuryl (ATC C04AX21) … Naftidrofuryl: Drug Effects, Side Effects, Dosage and Uses
Products Amyl nitrite is commercially available in the form of ampoules (Amyle Nitrite Inhalant USP). The product, available in many countries, is imported from abroad and is not officially approved as a drug. Amyl nitrite is included in the Federal Office of Public Health‘s antidote list and must be stocked in hospitals for the treatment … Amyl Nitrite
Products Regadenoson is commercially available as a solution for injection (Rapiscan). It was approved in the United States in 2008, in the EU in 2010, and in many countries in 2017. Structure and properties Regadenoson (C15H18N8O5, Mr = 390.4 g/mol) is present in the drug as a monohydrate. It is a derivative of adenosine. Effects … Regadenoson
Products Nicorandil is commercially available in tablet form (Dancor). It has been approved in many countries since 1993. Structure and properties Nicorandil (C8H9N3O4, Mr = 211.2 g/mol), like nitroglycerin, is an organic nitrate. It is a combination of the vitamin nicotinamide with an ethyl nitrate. Effects Nicorandil (ATC C01DX16) has vasodilator, antihypertensive, and cardioprotective properties. … Nicorandil
Products Nesiritide was commercially available in many countries as a powder for the preparation of an infusion solution (Noratak) and had been approved since 2003. Because of a new study of 7141 patients that failed to show a difference between nesiritide and placebo, the product was withdrawn from the market on Dec. 31, 2011 (O’Connor … Nesiritide
Products Pentoxifylline is commercially available in tablet form and as a solution for injection (generic). It has been approved in many countries since 1976. The original Trental is off the market. Structure and properties Pentoxifylline (C13H18N4O3, Mr = 278.3 g/mol) is an analog of theophylline. It is a white crystalline powder that is soluble in … Pentoxifylline: Drug Effects, Side Effects, Dosage and Uses
Products Molsidomine is commercially available in the form of tablets and sustained-release tablets (Corvaton). The drug has been approved in many countries since 1980. Structure and properties Molsidomine (C9H14N4O4, Mr = 242.2 g/mol) is a prodrug that is biotransformed in the liver to the active metabolite linsidomine (SIN-1). It exists as a white crystalline powder … Molsidomin
Products Buflomedil is no longer available as a drug in many countries. Loftyl is out of commerce. Structure and properties Buflomedil (C17H25NO4, Mr = 307.4 g/mol) exists as a white, microcrystalline powder that is readily soluble in water. Effects Buflomedil (ATC C04AX20) is vasoactive and α-adrenolytic. It inhibits platelet aggregation, improves erythrocyte deformability and regional … Buflomedil
