Boceprevir

Background It is estimated that more than 180 million people worldwide are chronically infected with the hepatitis C virus. Potential severe complications of hepatitis include cirrhosis, liver carcinoma, and liver failure. Of the various genotypes of the virus, genotype 1 in particular responds poorly to current treatment (50%). Standard drugs used include subcutaneous peginterferon alfa … Boceprevir

Pegaspargases

Products Pegaspargase is commercially available as an injectable (Oncaspar). The drug was approved in the United States in 2006, in the EU in 2016, and in many countries in 2017. Structure and properties Pegaspargase (PEG-L-asparaginase) is the pegylated enzyme L-asparaginase. The PEG units are covalently attached to the enzyme. Effects Pegaspargase (ATC L01XX24) has antileukemic … Pegaspargases

Insulin Aspart

Products Insulin aspart is marketed as an injectable (NovoRapid, USA: NovoLog). It has been approved in many countries since 1999. The fixed combination IDegAsp (insulin aspart + insulin degludec, Ryzodeg) was registered in many countries and in the EU in 2013. In 2017, Fiasp ultra-fast-acting, a very fast-acting insulin aspart, was also approved. With the … Insulin Aspart

Aspartic Acid

Products Dynamisan(+ arginine), see under arginine aspartate. Structure and properties Aspartic acid (C4H7NO4, Mr = 133.1 g/mol) Effects Aspartic acid (ATC V06CA). Indications Food supplementation States of exhaustion and weakness, convalescence (Dynamisan).

Aspartame

Products Aspartame is found in numerous products. It is available as a pure substance in specialized stores. Aspartame was accidentally discovered by James M. Schlatter at Searle in 1965. Structure and properties Aspartame (C14H18N2O5, Mr = 294.3 g/mol) exists as a white, crystalline, odorless, and slightly hygroscopic powder that is sparingly soluble in water (10 … Aspartame

What you Need to Know About Asparagus

From the end of April until the traditional finale on June 24, St. John’s Day, the popular but unfortunately far too short asparagus season lasts. While the healthy asparagus spears were once grown only in monasteries and apothecary gardens as a true panacea and later served as a royal vegetable to the rich and powerful, … What you Need to Know About Asparagus

Amino Acids

Products Some preparations containing amino acids are approved as medicinal products. These include, for example, methionine tablets or infusion preparations for parenteral nutrition. Amino acids are also marketed as dietary supplements, such as lysine, arginine, glutamine, and cysteine tablets. Protein powders such as whey protein can also be counted as amino acid supplements. Amino acids … Amino Acids

Granzyme: Structure, Function & Diseases

Granzymes consist exclusively of serine proteases found primarily in the granules of NK cells and cytotoxic T cells of the innate and acquired immune systems. The granzymes are released by degranulation upon recognition of a cell infected with viruses, a tumor cell, or even cells of transplanted foreign tissue. The released granzymes trigger programmed cell … Granzyme: Structure, Function & Diseases

Asparagus: Intolerance & Allergy

There are 220 types of asparagus, but only a few of them make it to the table. The most famous types are vegetable asparagus and Thai asparagus, although the season of vegetable asparagus is very limited. It is considered a delicacy and should not be missing from any menu during the season. Vegetable asparagus is … Asparagus: Intolerance & Allergy

Enteropeptidase: Function & Diseases

Enteropeptidase is an enzyme of the duodenal mucosa whose function is to activate pancreatic enzymes. It is at the beginning of an entire activation cascade of digestive enzymes. Dysfunction of enteropeptidase leads to maldigestion and malabsorption of food in the small intestine. What is an enteropeptidase? Enteropeptidase represents an enzyme of the duodenal mucosa that … Enteropeptidase: Function & Diseases