How bevacizumab works Bevacizumab is a monoclonal antibody that targets VEGF (vascular endothelial growth factor). In this way, its interaction with its binding site (receptor) is prevented. As a result, the formation of new blood vessels (angiogenesis) is inhibited, slowing tumor growth. While normal (healthy) cells eventually lose their ability to divide, this is not … Bevacizumab: Effects, Areas of Application, Side Effects
Pleural mesothelioma is a rare malignant tumor of the pleura. In most cases, the cause can be assumed to be long-term contact with asbestos dusts. The disease is not curable and can only be treated palliatively. What is pleural mesothelioma? Pleural mesothelioma represents a malignant tumor of the pleura, or pleura of the chest. It … Pleural Mesothelioma: Causes, Symptoms & Treatment
Symptoms Symptoms of Covid-19 include (selection): Fever Cough (irritating cough or with sputum) Respiratory disorders, shortness of breath, shortness of breath. Feeling sick, fatigue Cold symptoms: runny nose, stuffy nose, sore throat. Pain in the limbs, muscle and joint pain. Gastrointestinal complaints: Diarrhea, nausea, vomiting, abdominal pain. Nervous system: impairment of the sense of smell … COVID-19
Vascularization is the connection of an organ to the blood system and thus can also correspond to a new formation of smaller vessels. In the case of pathologic neovascularization, such as the systemic connection of a tumor, it is also referred to as neovascularization. In medical practice, vascularization plays a role mainly therapeutically. What is … Vascularization: Function, Tasks, Role & Diseases
Products The first therapeutic monoclonal antibody was approved in 1986. Muromonab-CD3 (Orthoclone OKT3) binds to the CD3 receptor on T cells and has been used in transplantation medicine. Numerous drugs containing antibodies are now available. A selection of active substances can be found at the end of this article. These are expensive drugs. For example, … Monoclonal Antibodies
Symptoms The possible initial symptoms of colon cancer include: Change in bowel habits, diarrhea or constipation. Bleeding, blood in the stool, black colored stool. Frequent urge to defecate, discharge of small and thin portions. Abdominal pain, flatulence, cramps. Weight loss, weakness, anemia Because the cancer grows slowly, it takes years before clinical symptoms finally appear. … Colon Cancer: Causes and Treatment
Products VEGF inhibitors are commercially available as injectables from various suppliers. The first agent in this group to be approved was pegaptanib (Macugen) in 2004, which is now off the market in many countries. Structure and properties The currently available VEGF inhibitors are therapeutic proteins (biologics). They are antibodies, antibody fragments, and fusion proteins. They … VEGF Inhibitors
Products Bevacizumab is commercially available as a concentrate for the preparation of an infusion solution (Avastin). It was approved in many countries and in the United States in 2004 and in the EU in 2005. Biosimilars have been approved in some countries and also in many countries. Structure and properties Bevacizumab is a recombinant, humanized … Bevacizumab
Products Ranibizumab is commercially available as a solution for injection (Lucentis). The drug was approved in the United States and many countries in 2006 and in the EU in 2007. The drug’s high price is controversial, especially when compared with bevacizumab (Avastin), which is structurally and pharmacologically similar. Bevacizumab is not approved for these indications … Ranibizumab
Introduction Chemotherapy for colorectal cancer represents the third important pillar in the treatment of cancer besides surgical removal and radiation. Chemotherapy is a mixture of different drugs, so-called cytostatics, which are administered to the patient in several stages over a longer period of time. They are designed to specifically identify and kill malignant cells on … Chemotherapy for colon cancer
Typical side effects of chemotherapy for colorectal cancer The drugs used in chemotherapy attack cells that divide quickly and have similar properties to cancer cells. In many cases, the body’s own healthy cells are also damaged, which can lead to various side effects. The most important side effects of chemotherapy are: By preventing rapid cell … Typical side effects of chemotherapy for colorectal cancer | Chemotherapy for colon cancer
What can you do if the chemotherapy does not work? In the treatment of colon cancer, chemotherapy is used in most cases when all visible parts of the cancer have already been surgically removed. Although the subsequent chemotherapy reduces the risk of recurrence, recurrences can still occur years later, especially in advanced stages. In the … What can you do if the chemotherapy does not work? | Chemotherapy for colon cancer
