Products Cabergoline is commercially available in tablet form (Cabaser, Dostinex). It has been approved in many countries since 1995. Structure and properties Cabergoline (C26H37N5O2, Mr = 451.6 g/mol) is a dopaminergic ergoline derivative. It exists as a white crystalline powder that is practically insoluble in water. Effects Cabergoline (ATC N04BC06) has dopaminergic properties and reduces … Cabergoline
Single administration Many medications are administered daily over a long period of time, such as agents for high blood pressure or lipid-lowering agents such as statins for disorders of lipid metabolism. However, various drugs also exist for which a single dose, i.e., a single administration, is sufficient. If necessary, it can be repeated after a … Single Dose
Definition Acromegaly refers to a pathological change in growth due to chronic somatotropin excess. The condition occurs primarily in individuals aged 40-50 years. If acromegaly is not adequately treated, life expectancy is shortened by approximately 10 years due to secondary diseases. Symptoms The symptoms of acromegaly initially remain inconspicuous. The symptoms are nonspecific and develop … Acromegaly: Too Much Growth Hormone
Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
Symptoms Symptoms depend on sex, age, adenoma size, and prolactin levels. In women, prolactinoma manifests as menstrual irregularities (absence or delay of periods), infertility, and lactation. In men, it results in testosterone deficiency, reduced libido, erectile dysfunction, impotence, decreased beard growth, and rarely breast pain and lactation. In children, puberty is additionally delayed. In a … Prolactinomas
When binding to a receptor, ligands and drugs have an effect on the target cell. Intrinsic activity is the strength of this effect. Antagonists have zero intrinsic activity and are intended only to prevent other ligands from binding to the receptor in question. What is intrinsic activity? When binding to a receptor, ligands and drugs … Intrinsic Activity: Function, Tasks, Role & Diseases
Indications For weaning Active ingredients Dopamine agonists inhibit the secretion of prolactin: Cabergoline (Dostinex) Bromocriptine (Parlodel)
Structure and properties Depending on the side chains, ergot alkaloids are classified into two different groups: Ergometrine-type ergot alkaloids (e.g., ergometrine, methylergometrine). Peptide-type ergot alkaloids (e.g., ergotamine, ergotoxine, bromocriptine). Effects Ergot alkaloids exhibit the following effects in varying degrees: Partial agonists at alpha-adrenoreceptors. Partial agonists at serotonin receptors Stimulation of dopamine receptors Contraction of vascular … Ergot Alkaloids
A dopamine agonist or dopamine antagonist is a drug that can stimulate dopamine receptors. Dopamine agonists are used to treat Parkinson’s disease, restless legs syndrome, and as emetics, among other conditions. What is a dopamine agonist? Dopamine agonists are used to treat Parkinson’s disease, restless legs syndrome, or as emetics, among other conditions. Dopamine agonists, … Dopamine Agonist: Effects, Uses & Risks
Cabergoline is the name given to a drug derived from ergot alkaloids. The drug is used to treat Parkinson’s disease, among other conditions. What is cabergoline? Cabergoline is the name given to a drug derived from ergot alkaloids. The drug is used to treat Parkinson’s disease, among other conditions. Cabergoline is an ergoline derivative. The … Cabergoline: Effects, Uses & Risks
