calcineurin inhibitors

Tacrolimus (Protopic, Prograf): Drug Effects, Side Effects, Dosage and Uses

Products Tacrolimus is commercially available in the form of capsules, sustained-release capsules, sustained-release tablets, as a concentrated solution for infusion, as granules, and as an ointment (Prograf, generic, Advagraf, Protopic, generic, Modigraf). It has been approved in many countries since 1996. This article refers to oral use; see also Topical Tacrolimus (Protopic Ointment). Structure and … Tacrolimus (Protopic, Prograf): Drug Effects, Side Effects, Dosage and Uses

Mifamurtid

Products Mifamurtide is commercially available as a powder for a concentrate for the preparation of an infusion dispersion (Mepact). It was approved in the EU in 2009 and in many countries in 2010. It was originally developed in the early 1980s at Ciba-Geigy. Structure and properties Mifamurtide (L-MTP-PE) is a fully synthetic derivative of muramyl … Mifamurtid

Immunosuppressants

Products Immunosuppressants are commercially available in numerous dosage forms, for example, as creams, ointments, tablets, capsules, solutions, eye drops, and injectables. Structure and properties Within immunosuppressants, several groups can be identified. These include steroids such as the glucocorticoids, substances of microbiological origin such as ciclosporin and mycophenolate mofetil, derivatives of nucleic acids and their components … Immunosuppressants

Itch

Physiological background Itch results from activation of specialized afferent unmyelinated C fibers in the skin. These fibers are anatomically identical to those that conduct pain but differ in function and stimulus transmission to the brain. They contain a number of receptors such as histamine receptors, PAR-2, endothelin receptor, and TRPV1, and mediators such as histamine, … Itch