How clomipramine works Clomipramine interacts with numerous docking sites (receptors) of nerve messengers (neurotransmitters). This explains its mood-lifting, anti-obsessive and analgesic effects. Signal transmission in the brain occurs via neurotransmitters such as serotonin and norepinephrine. When an electrical impulse excites a nerve cell, it releases a messenger into the synaptic cleft – a tiny gap … Clomipramine: effects, indications
Symptoms Sporadic, frequent, or chronic in onset: A bilateral pain originating in the forehead and extending along the sides of the head to the occipital bone at the back of the skull Pain quality: pulling, pressing, constricting, non-pulsating. Duration between 30 minutes and 7 days Mild to moderate pain, normal daily activities are possible Radiation … Tension Headache
Products Tricyclic antidepressants are commercially available in many countries in the form of dragées, tablets, capsules, and drops. The first representative, imipramine, was developed at Geigy in Basel. Its antidepressant properties were discovered in the 1950s by Roland Kuhn at the psychiatric clinic in Münsterlingen (Thurgau). Imipramine was approved in many countries in 1958. Structure … Tricyclic Antidepressants
Products Clomipramine is commercially available as sustained-release tablets and coated tablets (Anafranil). It has been approved in many countries since 1966 (originally Geigy, later Novartis). The injection and infusion preparations are no longer marketed. Structure and properties Clomipramine (C19H23ClN2, Mr = 314.9 g/mol) is present in drugs as clomipramine hydrochloride, a white to pale yellow … Clomipramine
Products Nicomorphine was commercially available in the form of tablets, suppositories, and as a solution for injection (Vilan). It had been approved in many countries since 1957. It was discontinued in 2015. Structure and properties Nicomorphine (C29H25N3O5, Mr = 495.5 g/mol), like heroin, is an ester as well as a nicotinic acid derivative of morphine … Nicomorphine
Symptoms In enuresis nocturna, a child older than 5 years empties the bladder repeatedly at night without an organic or medical cause. It does not wake up when the bladder is full and therefore cannot go to the toilet. During the day, on the other hand, everything works normally. The problem is slightly more common … Bedwetting (Enuresis Nocturna)
Background Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter biosynthesized from the amino acid tryptophan by decarboxylation and hydroxylation. It binds to seven different families of the serotonin receptor (5-HT1 to 5-HT7) and elicits central and peripheral effects that affect mood, behavior, sleep-wake cycle, thermoregulation, pain perception, appetite, vomiting, muscles, and nerves, among others. Serotonin is vasoconstrictive … Serotonin Syndrome: Causes and Treatment
Physiological background Itch results from activation of specialized afferent unmyelinated C fibers in the skin. These fibers are anatomically identical to those that conduct pain but differ in function and stimulus transmission to the brain. They contain a number of receptors such as histamine receptors, PAR-2, endothelin receptor, and TRPV1, and mediators such as histamine, … Itch
