Products Crizotinib has been approved in many countries since 2012 in capsule form (Xalkori). Structure and properties Crizotinib (C21H22Cl2FN5O, Mr = 450.3 g/mol) is an aminopyridine. It exists as a white to yellowish powder that is soluble in acidic solution to 10 mg/mL. Effects Crizotinib (ATC L01XE16) has antitumor and antiproliferative properties. The effects are … Crizotinib
Products Alectinib was approved in capsule form in Japan in 2014, in the United States in 2015, and in many countries in 2017 (Alecensa). Structure and properties Alectinib (C30H34N4O2, Mr = 482.6 g/mol) is present in the drug product as alectinib hydrochloride, a white to yellow-white powder. It has an active metabolite (M4). Effects Alectinib … Alectinib
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
Products Erlotinib is commercially available in the form of film-coated tablets (Tarceva). It has been approved in many countries since 2005. Generic versions were registered in 2018. Structure and properties Erlotinib (C22H23N3O4, Mr = 393.4 g/mol) is present in drugs as erlotinib hydrochloride, a white powder that is sparingly soluble in water. Solubility increases with … Erlotinib
Products Ceritinib is commercially available in capsule form (Zykadia). It was approved in the United States in 2014 and in the EU and many countries in 2015. In 2020, film-coated tablets were registered. Structure and properties Ceritinib (C28H36N5O3ClS, Mr = 558.14 g/mol) exists as a white to slightly yellow or slightly brown powder. Effects Ceritinib … Ceritinib
Symptoms Lung cancer may initially be asymptomatic. It is often discovered only when it is no longer curable. Possible typical symptoms include a chronic cough, coughing up blood, difficulty breathing, recurrent colds, chest pain, and weakness, fatigue, lack of appetite, and weight loss. If spread further, additional symptoms include hoarseness, noises when breathing, and difficulty … Lung Cancer Causes and Treatment
