Products Mitomycin is commercially available as a powder for the preparation of a solution for injection or infusion (Mitem). Structure and properties Mitomycin (C15H18N4O5, Mr = 334.3 g/mol) exists as a blue-violet crystalline powder or as crystals and is sparingly soluble in water. It is formed by a strain of. Mitomycin was first isolated in … Mitomycin
Products Ingenol mebutate was commercially available as a gel (Picato). It was approved in many countries in 2013, and in the EU and the U.S. as early as 2012. In 2020, approval was withdrawn because an increased risk of skin cancer was observed with the treatment. Structure and properties Ingenol mebutate (C25H34O6, Mr = 430.5 … Ingenol Mebutate
Products Amsacrine is commercially available as an infusion preparation (Amsidyl). It has been approved in many countries since 1993. Structure and properties Amsacrine (C21H19N3O3S, Mr = 393.5 g/mol) is an aminoacridine derivative. Effects Amsacrine (ATC L01XX01) has antineoplastic properties. The effects are due to inhibition of topoisomerase II. As a result, DNA synthesis is blocked. … Amsacrine
Products Cyclophosphamide is commercially available in the form of dragées and as a dry substance for intravenous infusion (Endoxan). It has been approved in many countries since 1960. Structure and properties Cyclophosphamide (C7H15Cl2N2O2P, Mr = 261.1 g/mol) is a cytostatic drug belonging to the group of oxazaphosphorines, nitrogen-lost derivative. Effects Cyclophosphamide (ATC L01AA01) has cytotoxic … Cyclophosphamide
Products Inotuzumab ozogamicin was approved in many countries, in the EU, and in the United States in 2017 as a powder for a concentrate for the preparation of an infusion solution (Besponsa). See also under gemtuzumab ozogamicin. Structure and properties Inotuzumab ozogamicin is an antibody-drug conjugate directed against CD22. Inotuzumab is a humanized lgG4 monoclonal … Inotuzumab Ozogamicin
Products Hydroxycarbamide is commercially available in the form of capsules (Litalir, generics). It has been approved in many countries since 1995. Structure and properties Hydroxycarbamide (CH4N2O2, Mr = 76.1 g/mol) is a hydroxylated urea (-hydroxyurea). It exists as a white, crystalline, hygroscopic powder that is readily soluble in water. Effects Hydroxycarbamide (ATC L01XX05) is cytostatic. … Hydroxycarbamide
Products Pemetrexed is commercially available as an infusion drug (Alimta, generic). It has been approved in many countries since 2005. Structure and properties Pemetrexed (C20H21N5O6, Mr = 427.4 g/mol) is a folic acid analog. It is present in drugs hydrated and as a disodium salt, in the original preparation as pemetrexed disodium heptahydrate, a white … Pemetrexed
Products Capecitabine is commercially available in the form of film-coated tablets (Xeloda, generic). It has been approved in many countries since 1998. Structure and properties Capecitabine (C15H22FN3O6, Mr = 359.4 g/mol) is a prodrug and is converted to the cell-toxic 5-fluorouracil, the active drug, in a three-step process. Capecitabine exists as a white crystalline powder … Capecitabine
Products Decitabine is commercially available as a lyophilizate for the preparation of a concentrate for infusion solution (Dacogen). It has been approved in many countries and in the EU since 2012. Structure and properties Decitabine (C8H12N4O4, Mr = 228.2 g/mol) or 5-aza-2′-deoxycytidine is an analog of cytidine deoxynucleoside and differs from deoxycytidine by a C … Decitabine
Products Estramustine phosphate is commercially available in the form of capsules (Estracyt). It has been approved in many countries since 1977. Structure and properties Estramustine phosphate (C23H30Cl2NNa2O6P, Mr = 564.3 g/mol) is an estradiol phosphate ester linked via a carbamate linkage to noritrogen solstice, and is a prodrug. Effects Estramustine phosphate (ATC L01XX11) has cytostatic … Estramustine Phosphate
Products Trabectedin is commercially available as a powder for the preparation of an infusion solution concentrate (Yondelis). It has been approved in many countries since 2009. Structure and properties Trabectedin (C39H43N3O11S, Mr = 761.8 g/mol) is a tetrahydroisoquinoline alkaloid from sea squirt , a marine animal belonging to the tunicates. The active ingredient is produced … Trabectedin
Background Kinases (phosphotransferases) are a large family of enzymes involved in the transduction and amplification of signals on and in cells. They exert their effects by phosphorylating their substrates, that is, by adding a phosphate group to the molecules (Figure). Kinases have complicated names that are usually abbreviated: ALK, AXL, BCR-ABL, c-Kit, c-Met, ERBB, EGFR, … Kinase Inhibitors
