Products Dexmedetomidine is commercially available as a concentrate for the preparation of an infusion solution (Dexdor). It was approved in many countries in 2012. Structure and properties Dexmedetomidine (C13H16N2, Mr = 200.3 g/mol) is an imidazole derivative and the -enantiomer of medetomidine. It is structurally closely related to detomidine and is present in drugs as … Dexmedetomidine
Products Abametapir was approved in the United States in 2020 as an emulsion for external use (Xeglyze). Structure and properties Abametapir (C12H12N2, Mr = 184.24 g/mol) consists of two molecules of methylpyridine covalently bonded together. The active ingredient is present as an oil-in-water emulsion. Effects Abametapir has insecticidal and ovicidal properties, meaning it kills both … Abametapir
Products Efavirenz is commercially available as film-coated tablets and as an oral solution (Stocrin, combination products, generics). It has been approved in many countries since 2001. Structure and properties Efavirenz (C14H9ClF3NO2, Mr = 315.7 g/mol) exists as a white to light pink crystalline powder that is practically insoluble in water. It has a non-nucleoside structure … Efavirenz
Products Prasugrel is commercially available in the form of film-coated tablets (Efient). It was approved in many countries, in the EU and in the US in 2009. Generic versions were registered in 2019. Structure and properties Prasugrel (C20H20FNO3S, Mr = 373.4 g/mol) belongs to the group of thienopyridines and exists as a hydrochloride as a … Prasugrel
Products Esketamine nasal spray was approved in the US and EU in 2019 and in many countries in 2020 (Spravato). Structure and properties –Ketamine is the pure -enantiomer of ketamine (C13H16ClNO, Mr = 237.7 g/mol). The racemate ketamine is a cyclohexanone derivative derived from phencyclidine (“angel dust”). It is a ketone and an amine and … Esketamine Nasal Spray
Products Phenobarbital is commercially available in tablet form and as a solution for injection (aphenylbarbit, phenobarbital Bichsel). It was approved in many countries in 1944. Luminal has been off the market in many countries since late August 2011. Barbexaclone (maliasin), a fixed combination of phenobarbital and L-propylhexedrine, is also no longer available. Structure and properties … Phenobarbital
Products Modafinil is commercially available in tablet form (CH: Modasomil-100, Modafinil-Acino, DL: Vigil, USA: Provigil). It has been approved in the EU since 1992, in the US since 1998, and in many countries since 2000. Structure and properties Modafinil or 2-benzhydrylsulfinylacetamide (C15H15NO2S, Mr = 273.35 g/mol) is a racemate and exists as a white crystalline … Modafinil
Products Clobazam is commercially available in tablet form (Urbanyl). It has been approved in many countries since 1979. Structure and properties Clobazam (C16H13ClN2O2, Mr = 300.7 g/mol) exists as a white crystalline powder that is sparingly soluble in water. It belongs structurally to the 1,5-benzodiazepines. The other active ingredients are 1,4-benzodiazepines. Effects Clobazam (ATC N05BA09) … Clobazam
Products Osilodrostate was approved in many countries, in the EU and in the US in 2020 in the form of film-coated tablets (Isturisa). Structure and properties Osilodrostat (C13H10FN3, Mr = 227.24 g/mol) is present in the drug as osilodrostat phosphate. Effects Osilodrostate (ATC H02CA02) inhibits the biosynthesis of cortisol. The effects are due to inhibition … Osilodrostatic
