Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Products Paritaprevir was approved in many countries in 2014 in film-coated tablet form (Viekirax, combination drug). Effects Paritaprevir has antiviral properties against HCV. The effects are due to binding to the NS3/4A protease complex. HCV NS3 serine protease is an enzyme involved in viral replication. To increase availability and allow once-daily administration, paritaprevir is combined … Paritaprevir
Products Dasabuvir is commercially available in the form of film-coated tablets. It was approved in many countries in 2014 (Exviera). Structure and properties Dasabuvir (C26H27N3O5S, Mr = 493.6 g/mol) has a non-nucleoside structure. It exists in the drug as a sodium salt and as a monohydrate. Effects Dasabuvir (ATC J05AX16) has antiviral properties. The effects … Dasabuvir
Products Ombitasvir was approved in the EU and many countries in 2014 in film-coated tablet form (Viekirax, combination drug). Structure and properties Ombitasvir (C50H67N7O8, Mr = 894.1 g/mol) Effects Ombitasvir (ATC J05AX66) has antiviral properties against HCV virus. The effects are due to binding to the viral protein NS5A (Non-Structural Protein 5A). Unlike other HCV … Ombitasvir
Symptoms Most patients have no symptoms. The disease may manifest as fatigue, nausea, loss of appetite, muscle and joint pain, and weight loss. Potential longer-term dangerous complications of chronic infection that can develop over years include cirrhosis and liver cancer. This eventually often makes liver transplantation necessary. Causes The cause of the symptoms is infection … Hepatitis C Symptoms, Causes and Treatment
What drugs are used for hepatitis C? Until 2014, hepatitis C was treated mainly with interferon and drugs that inhibit the multiplication of the virus. In most cases, interferon-α was administered in combination with ribavirin. Since 2015, new drugs that directly attack the virus have been approved. NS5-A inhibitors (Ledipasvir, Daclatasvir, Ombitasvir), NS5-B inhibitors (Sofosbuvir, … Medicines for hepatitis C
Ribavirin Rivavirin is a drug used to treat certain viral infections, a so-called antiviral drug. In chronic hepatitis C, ribavirin is administered in combination with interferon-α to prevent the hepatitis C-induced form of liver inflammation from worsening and to prevent progressive functional impairment of the liver. The active ingredient ribavirin inhibits the multiplication of viruses … Ribavirin | Medicines for hepatitis C
Costs Agents that end in -buvir have been available in Germany since 2014, whereby one tablet costs around €488. This corresponds to therapy costs of 43. 500€ for a person over 12 weeks. A pack for a four-week therapy with the drug Simeprevir costs about 9. 360€. Therapy with new drugs that end on -asvir, … Costs | Medicines for hepatitis C
