degradation

If Paget’s disease is suspected, an X-ray examination will usually confirm the diagnosis: The rapid, “sloppy” bone formation, structural changes, thickening and deformation of the bone tissue can be easily seen. A bone scintigraphy may be taken to show the increased metabolic activity in the bone. Supportive blood or urine tests are performed, which show … Paget’s Disease: Therapy and Diagnosis

In healthy bone, formation and degradation are in balance. This is disturbed in Paget’s disease. Many patients are symptom-free, while others experience various symptoms. Paget’s disease is named after its first describer, the British physician Sir James Paget. It is also called “Paget’s disease of the bone” (to distinguish it from Paget’s carcinoma, “Paget’s disease … Paget’s Disease: Symptoms, Diagnosis, Therapy