Products Diphenoxylate is not commercially available in many countries. Combination products with atropine sulfate are commercially available in the United States. Structure and properties Diphenoxylate (C30H32N2O2, Mr = 452.6 g/mol) is present in drugs as diphenoxylate hydrochloride, a white crystalline powder that is very sparingly soluble in water. It is a derivative of pethidine and … Diphenoxylate
Products Difenoxin is not commercially available in many countries. Structure and properties Difenoxin (C28H28N2O2, Mr = 424.5 g/mol) is the active metabolite of diphenoxylate and structurally related to loperamide (Imodium). Effects Difenoxin (ATC A07DA04) is peristaltic inhibitory and antidiarrheal. Indication Diarrhea
Products Loperamide is commercially available in the form of capsules, film-coated tablets, melting tablets, and as a syrup (Imodium, generic). It has been approved in many countries since 1977. Structure and properties Loperamide (C29H33ClN2O2, Mr = 477.0 g/mol) is a piperidine derivative and has structural similarities to the neuroleptic haloperidol and the peristaltic inhibitor diphenoxylate. … Loperamide: Drug Effects, Side Effects, Dosage and Uses