Products Rasagiline is commercially available in tablet form (Azilect). It has been approved in many countries since 2005. Generic versions were first released in 2015. Structure and properties Rasagiline (C12H13N, Mr = 171.24 g/mol) is an aminoindan derivative and has an asymmetric carbon atom. Therapeutic uses are found for the -enantiomer. It is present in … Rasagiline
Products Rotigotine is commercially available as a transdermal patch in various potencies (Neupro). It was approved in many countries in 2006 as the first TTS for Parkinson’s disease therapy. Structure and properties Rotigotine (C19H25NOS, Mr = 315.5 g/mol) is an aminotetralin and thiophene derivative structurally related to dopamine. It has a non-ergoline structure and exists … Rotigotine
Products Pergolide (Permax) had been approved in tablet form in many countries since 1997. On Sept. 30, 2011, Permax went off the market in many countries. The reason given for the market withdrawal was a fire at the packaging plant. Other dopamine agonists are available as alternatives. Structure and properties Pergolide (C19H26N2S, Mr = 314.5 … Pergolide
Products Ropinirole is commercially available in the form of film-coated tablets (Adartrel, Requip, generic). It has been approved in many countries since 1996. Structure and properties Ropinirole (C16H24N2O, Mr = 260.4 g/mol) is a non-ergoline dopamine agonist and a dihydroindolone derivative. It is present in drugs as ropinirole hydrochloride, a white to yellow powder that … Ropinirole
Products Dopamine is commercially available as an infusion solution concentrate (Dopamine Sintetica). It has been approved in many countries since 1975. Structure and properties Dopamine (C8H11NO2, Mr = 153.2 g/mol) is an endogenous substance formed from DOPA by decarboxylation and can be oxidized to norepinephrine. Effects Dopamine (ATC C01CA04) has sympathomimetic and dopaminergic properties. Effects … Dopamine Neurotransmitter
Products Dopamine agonists are commercially available in the form of tablets, sustained-release tablets, transdermal patches, and injectables, among others. Structure and properties The first active ingredients, such as bromocriptine (Figure), were derived from ergot alkaloids. These are referred to as ergoline dopamine agonists. Later, agents with a nonergoline structure, such as pramipexole, were also developed. … Dopamine Agonists
Products Selegiline was commercially available in tablet form (Jumexal, generic). The drug was available in many countries from 1985 to 2016. Structure and properties Selegiline (C13H17N, Mr = 187.28 g/mol) is present in drugs as selegiline hydrochloride, a white crystalline powder that is readily soluble in water. Effects Selegiline (ATC N04BD01) has indirect dopaminergic and … Selegiline
Products Pramipexole is commercially available in tablet and sustained-release tablet form (Sifrol, Sifrol ER, generics). It has been approved in many countries since 1997; generics were released in 2010 and entered the market in January 2011. Sifrol ER sustained-release tablets were relaunched by the original manufacturer in 2010. Structure and properties Pramipexole (C10H17N3S, Mr = … Pramipexole
Products Safinamide is commercially available in the form of film-coated tablets (Xadago). It was approved in many countries and in the EU in 2015 and in the US in 2017. Structure and properties Safinamide (C17H19FN2O2, Mr = 302.3 g/mol) is an α-aminoamide derivative. Effects Safinamide (ATC N04BD03) has indirect dopaminergic properties. It is a selective … Safinamide
