Products Medicines containing oxedrine (synephrine) are no longer available in many countries. Sympalept is out of commerce. Structure and properties Oxedrine (C9H13NO2, Mr = 167.21 g/mol) is a structurally related to epinephrine and is present in drugs as oxedrine tartrate. It is also referred to as synephrine. Effects Oxedrine (ATC C01CA08) has sympathomimetic properties and … Oxedrine
Products Medicines containing oxilofrine are not commercially available in many countries. In some countries, it has been marketed in the form of drops and dragées (Carnigen). Structure and properties Oxilofrin (C10H15NO2, Mr = 181.2 g/mol) is present in drugs as oxilofrine hydrochloride and is also known as methylsynephrine. It is structurally related to ephedrine and … Oxilofrin
Products Mirabegron is commercially available in the form of sustained-release film-coated tablets (Betmiga, USA: Myrbetriq). It was approved in the US and EU in 2012 and in many countries in 2014. Mirabegron was the first agent from the beta3 agonist group to be approved for the treatment of irritable bladder. It was originally intended to … Mirabegron
Products Numerous nasal sprays containing vasoconstrictive agents are commercially available. Among the best known are xylometazoline (Otrivin, generic) and oxymetazoline (Nasivin). In addition to sprays, nasal drops and nasal gels are also available. Decongestants for the nose have been available since the early 20th century (Sneader, 2005). As early as the 1940s, rhinitis medicamentosa was … Decongestant Nasal Sprays
Products Amphetamines are commercially available as drugs in the form of tablets, sustained-release tablets, capsules, and sustained-release capsules. Structure and properties Amphetamines are derivatives of amphetamine. It is a methylphenethylamine structurally related to endogenous monoamines and stress hormones epinephrine and norepinephrine. Amphetamines are racemates and the –enantiomers. Effects Amphetamines have sympathomimetic, central stimulant, bronchodilator, psychoactive, … Amphetamines
Products Beta2-sympathomimetics are usually commercially available as inhalation preparations (powders, solutions) administered with an inhaler, for example, metered-dose inhaler, diskus, Respimat, Breezhaler, or Ellipta. There are few drugs on the market that can be given perorally. Structure and properties Beta2-sympathomimetics are structurally related to the natural ligands epinephrine and norepinephrine. They may exist as racemates … Beta2-Sympathomimetics
Products Tramazoline is commercially available in the form of nasal sprays, nasal drops, and as eye drops. The drugs are not registered in many countries. Structure and properties Tramazoline (C13H17N3, Mr = 215.3 g/mol) is an imidazoline derivative structurally related to naphazoline, oxymetazoline, and xylometazoline. Effects Tramazoline (ATC S01GA) is a vasoconstrictor and decongestant. The … Tramazoline
Caniphedrine The alkaloid L-ephedrine is found along with other alkaloids in plants of the genus Ephedra (e.g., Stapf, Ephedraceae). The herb has been used in Chinese medicine under the name Ma Huang for over 5000 years. In the 16th century pharmacopoeia Pentsao Kang Mu by Li Shih-Chen, it is recommended as a circulatory stimulant, diaphoretic, … Cave Canem: Caniphedrine
Products Isoprenaline was newly approved in many countries in the fall of 2010 as a solution for injection/concentrate for the preparation of an infusion solution (Isuprel). Structure and properties Isoprenaline (C11H17NO3, Mr = 211.3 g/mol) is a methyl derivative of epinephrine and a racemate. It is present in the drug as isoprenaline hydrochloride, a white … Isoprenaline
Products Methylephedrine is sold in many countries exclusively in the form of capsules in combination with other active ingredients (Tossamine plus). Structure and properties Methylephedrine (C11H17NO, Mr = 179.3 g/mol) Effects Methylephedrine has bronchospasmolytic properties. Indications Tossamine plus is approved for the treatment of cough not associated with excessive mucus production.
Products Dobutamine is commercially available as an infusion solution (Dobutrex). It has been approved in many countries since 1988. Structure and properties Dobutamine (C18H23NO3, Mr = 301.4 g/mol) is present in drugs as racemate and dobutamine hydrochloride, a white crystalline powder that is sparingly soluble in water. Effects ATC C01CA07 Stimulation of β1-adrenergic receptors. Positively … Dobutamine
Products Pseudoephedrine is commercially available in the form of capsules, tablets, and granules, among others. Apart from Rinoral (formerly Otrinol), these are combination products (e.g., Pretuval). Pseudoephedrine is mainly found in cold remedies. Structure and properties Pseudoephedrine (C10H15NO, Mr = 165.2 g/mol) is present in drugs as pseudoephedrine hydrochloride, a white crystalline powder or as … Pseudoephedrine
