Products Azacitidine is commercially available as a lyophilizate for the preparation of a suspension for injection (Vidaza, generic). It has been approved in many countries since 2006. Structure and properties Azacitidine (C8H12N4O5, Mr = 244.2 g/mol) is a derivative of the nucleoside cytidine found in nucleic acids. It belongs to the pyrimidine nucleoside analogues. Azacitidine … Azacitidine
Products Ritonavir is commercially available as a monopreparation in the form of film-coated tablets (Norvir). It was approved in many countries, in the United States and in the EU in 1996, and is also used as a pharmacokinetic booster in combination with antiviral agents (eg, lopinavir). Norvir syrup is no longer marketed in many countries. … Ritonavir
Symptoms Drug-induced prolongation of the QT interval can rarely lead to severe arrhythmias. This is polymorphic ventricular tachycardia, known as torsade de pointes arrhythmia. It can be seen on the ECG as a wave-like structure. Due to the dysfunction, the heart cannot maintain blood pressure and can only pump insufficient blood and oxygen to the … Prolongation of the QT Interval
Intestinal absorption After ingestion of a drug, the active ingredient must first be released. This process is called release (liberation), and it is a prerequisite for subsequent absorption. Absorption (formerly: resorption) is the passage of an active pharmaceutical ingredient from the digestive pulp into the bloodstream in the stomach and intestines. Absorption occurs primarily in … Absorption
Products Ocrelizumab was approved in many countries and in the United States in 2017 and in the EU in 2018 as an infusion concentrate (Ocrevus). Structure and properties Ocrelizumab is a humanized IgG1 monoclonal antibody with a molecular mass of 145 kDa. It is produced by biotechnological methods. Ocrelizumab is the successor agent to rituximab … Ocrelizumab
Products Susoctocog alfa is commercially available as a powder and solvent for solution for injection (Obizur). It was approved in the United States in 2014, in the EU in 2015, and in many countries in 2016. Structure and properties Susoctocog alfa is a recombinant derivative of porcine blood clotting factor VIII lacking the B domain. … Susoctocog Alfa
Products Sunitinib is commercially available in capsule form (Sutent). It has been approved in many countries since 2006. Structure and properties Sunitinib (C22H27FN4O2, Mr = 398.5 g/mol) is present in the drug as sunitinibmalate, a yellow to orange powder that is soluble in water. It is an indolin-2-one and pyrrole derivative. It has an active … Sunitinib
Products Pasireotide is commercially available as an injectable (Signifor, Signifor LAR). It was approved in the EU and many countries in 2012. Structure and properties Pasireotide (C59H67N9O9, Mr = 1046.2 g/mol) is present in the drug as pasireotide diaspartate or as pasireotide pamoate. It is a cyclohexapeptide and an analog of the hormone somatostatin. Somatostatin … Pasireotide
Products Medicinal mushrooms are commercially available, for example, in the form of capsules, tablets and as powders as dietary supplements or as individually prepared mixtures. Also used are the pure ingredients that are extracted, synthetically produced or semi-synthetically modified. These are usually registered as medicinal products. About mushrooms Fungi are a very diverse group of … Medicinal Mushrooms
Definition and mechanisms A pharmacokinetic booster is an agent that improves the pharmacokinetic properties of another agent. It is a desirable drug interaction It can exert its effects at different levels (ADME): Absorption (uptake into the body). Distribution (distribution) Metabolism and first-pass metabolism (metabolization). Elimination (excretion) Pharmacokinetic enhancers can increase absorption, increase distribution to an … Pharmacokinetic Booster
Products Sofosbuvir is commercially available in the form of film-coated tablets (Sovaldi). It was approved in the United States and EU in 2013 and in many countries in 2014. The very high price of the drug has been a source of debate. Sofosbuvir is also combined fixed with ledipasvir (Harvoni). Cheaper generics are available in … Sofosbuvir
Products Thiamine (vitamin B1) is commercially available in tablet form and as a solution for injection (e.g., Benerva, Neurorubin, generics), among others. It is a component of numerous combination preparations (e.g., Berocca). Structure and properties Thiamine (C12H17N4OS+, Mr = 265.4 g/mol) is usually present in drugs as thiamine nitrate or thiamine hydrochloride. Thiamine hydrochloride, unlike … Thiamine (Vitamin B1)
