Products Catridecacog is used as a powder and solvent for the preparation of a solution for injection (NovoThirteen). It was approved in many countries in 2012. Structure and properties Catridecacog is the recombinant blood clotting factor XIII A subunit and is equivalent to the human FXIII A subunit. Effects Catridecacog (ATC B02BD11) is effective against … Catridecacog
Products Susoctocog alfa is commercially available as a powder and solvent for solution for injection (Obizur). It was approved in the United States in 2014, in the EU in 2015, and in many countries in 2016. Structure and properties Susoctocog alfa is a recombinant derivative of porcine blood clotting factor VIII lacking the B domain. … Susoctocog Alfa
Products Damoctocog alfa pegol was approved as a preparation for solution for injection in the United States and the EU in 2018 and in many countries in 2019 (Jivi). Structure and properties Damoctocog alfa pegol is a pegylated, B-domain-deleted, conjugated, recombinant blood coagulation factor VIII (rFVIII). The molecular mass is approximately 234 kDa. The drug … Damoctocog Alfa Pegol
Products Octocog alfa is commercially available as an injectable. It has been approved in many countries since 2004. Structure and properties Octocog alfa is the recombinant blood clotting factor VIII produced by biotechnological methods. In the past, it was also obtained from plasma, but this posed a risk for the transmission of infectious diseases. Octocog … Octocog Alfa
Products Efmoroctocog alfa was approved in many countries in 2016 as a powder and solvent for the preparation of a solution for injection (Elocta). Structure and properties Efmoroctocog alfa is a recombinant fusion protein consisting of human coagulation factor VIII without the B domain covalently bound to the Fc domain of human immunoglobulin G1. The … Efmoroctocog Alfa
Products Eftrenonacog alfa was approved in the United States in 2014 and in the EU and many countries in 2016 as a powder and solvent for solution for injection (Alprolix). Structure and properties Eftrenonacog alfa is a recombinant fusion protein consisting of human coagulation factor IX covalently linked to the Fc fragment of human immunoglobulin … Eftrenonacog Alfa
Products Vonicog alfa was approved in the United States in 2015 and in the EU and Switzerland in 2018 as a lyophilizate and solvent for the preparation of a solution for injection (Veyvondi, USA: Vonvendi). It was the first recombinant von Willebrand factor. Structure and properties Vonicog alfa is a purified, recombinant, human von Willebrand … Vonicog Alfa
Products Albutrepenone acog alfa was approved in many countries and in the EU in 2016 as a powder and solvent for the preparation of a solution for injection for intravenous use (Idelvion). Structure and properties Albutrepenonacog alfa is a recombinant fusion protein consisting of recombinant blood clotting factor IX combined with recombinant albumin. It is … Albutrepenonacog Alfa
Products Rurioctocog alfa pegol was approved in many countries in 2016 as a lyophilizate and solvent for the preparation of a solution for intravenous injection (Adynovi). Structure and properties Rurioctocog alfa pegol is a pegylated recombinant human blood coagulation factor VIII (octocog alfa). Pegylation results in a prolonged half-life. Effects Rurioctocog alfa pegol (ATC B02BD02) … Rurioctocog Alfa Pegol
Products Turoctocog alfa is commercially available as a powder and solvent for solution for injection (NovoEight). It has been approved in many countries since 2014. See also under turoctocog alfa pegol (pegylated drug). Structure and properties Turoctocog alfa is an activated human blood coagulation factor VIII produced by biotechnological methods and truncated at the B … Turoctocog Alfa
Products Turoctocog alfa pegol was approved in the US, EU, and many countries in 2019 as a powder and solvent for solution for injection (Esperoct). Structure and properties Turoctocog alfa pegol is a recombinant and modified human factor VIII (rFVIII) produced by biotechnological methods. A polyethylene glycol (PEG) with a molecular mass of 40 kDa … Turoctocog Alfa Pegol
Products Moroctocog alfa is commercially available as a lyophilizate (ReFacto). It has been approved in many countries since 2000. Structure and properties Moroctocog alfa is a recombinant blood clotting factor VIII produced by biotechnological methods. It is a glycoprotein with 1438 amino acids and a molecular mass of 170 kDa. The B domain has been … Moroctocog Alfa
